Variable name | HR | 95% CI | P value |
NEDA-2 (year 0–5) | 0.428 | 0.334 to 0.549 | <0.0001 |
Active disease (year 0–5) | Reference | ||
NEDA-2 (year 5–10) | 0.636 | 0.399 to 1.013 | 0.0565 |
Active disease (year 5–10) | Reference | ||
NEDA-2 (>10 years) | 0.917 | 0.261 to 3.223 | 0.8923 |
Active disease (>10 years) | Reference | ||
Age at index date: 18–24 years | Reference | ||
Age at index date: 25–29 years | 1.484 | 0.947 to 2.325 | 0.850 |
Age at index date: 30–34 years | 1.242 | 0.788 to 1.958 | 0.3507 |
Age at index date: 35–39 years | 1.537 | 0.982 to 2.406 | 0.0603 |
Age at index date: 40–44 years | 1.823 | 0.152 to 2.883 | 0.0103 |
Age at index date:>44 years | 2.626 | 1.704 to 4.205 | <0.0001 |
Disease duration | 1.049 | 1.011 to 1.089 | 0.0014 |
No relapse 24 months before treatment start | 0.987 | 0.907 to 1.074 | 0.7634 |
Socioeconomic status at treatment start: employee, low skilled | Reference | ||
Socioeconomic status at treatment start employee, moderate-high skilled | 0.532 | 0.413 to 0.685 | <0.0001 |
Socioeconomic status at treatment start: chief executive in a public institution | 0.527 | 0.233 to 1.191 | 0.1236 |
Socioeconomic status at treatment start: educational support | 0.589 | 0.346 to 1.002 | 0.0508 |
Socioeconomic status at treatment start: leave of absence (sick leave, parental leave) | 2.357 | 1.639 to 3.389 | <0.0001 |
Socioeconomic status at treatment start: own Business | 0.486 | 0.228 to 1.037 | 0.0622 |
Socioeconomic status at treatment start: unemployed for >6 months of the year | 1.560 | 1.082 to 2.248 | 0.0622 |
Socioeconomic status: other | 0.833 | 0.425 to 1.633 | 0.5950 |
Calendar year at index date | 0.900 | 0.872 to 0.928 | <0.0001 |
EDSS level at treatment start EDSS 0 | Reference | ||
EDSS level at treatment start EDSS 1–2.5 | 1.475 | 1.013 to 2.147 | 0.0425 |
EDSS level at treatment start EDSS 3–3.5 | 2.027 | 1.337 to 3.074 | 0.0009 |
EDSS level at treatment start EDSS 4–4.5 | 2.626 | 1.452 to 4.749 | <0.0001 |
EDSS, Expanded Disability Status Scale; NEDA, No Evidence of Disease Activity.