Baseline and neuroimaging characteristics of the whole population and the population with complete follow-up
| n=277 | n=227 (complete follow-up) | |
| Age, years (SD) | 68.0 (8.0) | 67.0 (7.6) |
| Sex, men (%) | 155 (56) | 127 (56) |
| Education, median (range) | 5 (5–6) | 5 (5–6) |
| MMSE, median (range) | 29 (28–30) | 29 (28–30) |
| Vascular risk factors | ||
| Hypertension, n (%) | 219 (79) | 172 (76) |
| Diabetes, n (%) | 35 (13) | 25 (11) |
| Smokers, n (%) | 38 (14) | 30 (13) |
| Hypercholesterolaemia, n (%) | 121 (44) | 94 (41) |
| Body mass index, mg/kg2, mean (SD) | 27.8 (4.7) | 27.7 (4.2) |
| Neuroimaging | ||
| WMH, mL, median (range) | 2.9 (1.3–8.1) | 2.5 (1.1–6.4) |
| Lacunes, n (%) | 65 (23.5) | 46 (20.3) |
| Microbleeds, n (%) | 53 (19.1) | 32 (14.1) |
| Total brain volume, mL (SD) | 1073 (104) | 1086 (104) |
| Mean diffusivity (SD) | 8.2×10−4 (3.9×10−5) | 8.2×10−4 (3.7×10−5) |
| Network density (SD) | 0.52 (0.02) | 0.53 (0.01) |
| Network strength (SD) | 75.8 (6.2) | 76.3 (5.8) |
| Global efficiency (SD) | 142.1 (16.2) | 144.3 (14.5) |
Data represent mean±SD, n of participants (%) or median (IQR).
MMSE, Mini Mental State Examination; WMH, white matter hyperintensities.