Table 2

Diagnostic accuracy of CSF and blood KLK8 (unadjusted analyses)

AD versus CONMCI versus CON
CSF KLK8Blood KLK8CSF KLK8Blood KLK8
Cut-off (pg/mL)2603973421121
Sensitivity (%) (95% CI)65.0 (48.3 to 79.4)56.1 (45.7 to 66.1)91.7 (61.5 to 99.8)52.4 (29.8 to 74.3)
Specificity (%) (95% CI)88.6 (73.3 to 96.8)69.8 (60.7 to 77.8)94.3 (80.8 to 99.3)99.2 (95.4 to 100.0)
Accuracy (%) (95% CI)76.0 (64.8 to 85.1)63.6 (56.8 to 70.0)93.6 (82.5 to 98.7)92.1 (86.4 to 96.0)
OR (95% CI)14 (4 to 49)2.95 (1.7 to 5.2)182 (15 to 2201)130 (15 to 1110)
  • AD, Alzheimer’s disease;CI, confidence interval; CON, controls; CSF, cerebrospinal fluid; KLK8, Kallikrein-8; MCI, mild cognitive impairment due to AD; OR, odds ratio.