Table 3

Sensitivity analyses for unadjusted AUCs

		AUC (95% CI) (unadjusted analyses)
		All AD patients All MCI patients All CON participants	All AD patients All MCI patients CON: healthy and headache only	All AD patients All MCI patients CON: psychiatric and PD only	All participants minus study group B
AD versus CON	CSF KLK8	0.80 (0.70 to 0.90)	0.70 (0.55 to 0.83)	0.96 (0.90 to 1.0)	0.80 (0.70 to 0.90)
AD versus CON	Blood KLK8	0.67 (0.60 to 0.74)	0.60 (0.51 to 0.68)	0.76 (0.67 to 0.85)	0.70 (0.62 to 0.77)
MCI versus CON	CSF KLK8	0.94 (0.86 to 1.0)	0.91 (0.77 to 1.0)	0.99 (0.98 to 1.0)	0.94 (0.86 to 1.0)
MCI versus CON	Blood KLK8	0.70 (0.55 to 0.85)	0.65 (0.48 to 0.83)	0.77 (0.64 to 0.90)	0.88 (0.74 to 1.0)

AUCs of CSF and blood KLK8 for discrimination of AD or MCI from controls are shown for different subgroups of participants. The first column shows data for all participants. In the second column patients with psychiatric diseases or PD and in the third column patients with tension-type headache and healthy volunteers are excluded. The fourth column represents the AUC values for all participants after exclusion of study group B (with blood samples only). Please note that AUC values of the sensitivity analyses are not adjusted and that adjustment in the main analysis was associated with an increase of the AUC.
AD, Alzheimer’s disease; AUC, area under the curve; CI, confidential interval; CON, controls; CSF, cerebrospinal fluid; Headache, patients with tension-type headache; Healthy, healthy volunteers; KLK8, Kallikrein-8; MCI, mild cognitive impairment due to AD;PD, Parkinson’s disease; Psychiatric, patients with psychiatric diagnoses.