Adjusted mean differences in plasma NfL concentrations between groups with 95% bias-corrected bootstrap CI
| NfL | C9orf72 PS | C9orf72 S | GRN PS | GRN S | MAPT PS | MAPT S |
| Controls |
9.0*
(1.3 to 26.8) |
29.7**
(18.7 to 47.5) | 0.0 (−3.1 to 3.3) |
70.5**
(51.6 to 92.6) | 0.9 (−2.2 to 6.4) |
12.6*
(3.3 to 26.1) |
| C9orf72 PS |
20.7*
(3.2 to 36.1) | −9.0*
(−27.5 to −1.4) |
61.4**
(37.7 to 82.7) | −8.1*
(−27.0 to −0.6) | 3.6 (−15.6 to 17.0) | |
| C9orf72 S | −29.8**
(−47.7 to −18.7) |
40.7**
(16.5 to 62.2) | −28.9**
(−46.2 to −16.9) | −17.2*
(−35.7 to −2.9) | ||
| GRN PS |
70.5**
(52.5 to 92.2) | −0.9 (−5.9 to 2.9) |
12.6*
(2.9 to 25.2) | |||
| GRN S | −69.6**
(−91.7 to −50.6) | −57.9**
(−81.5 to −36.8) | ||||
| MAPT PS |
11.7*
(0.8 to 23.4) |
Significant differences in bold: *p<0.05; **p<0.01.
NfL, neurofilament light chain; PS, presymptomatic; S, symptomatic.