Table 2

Adjusted mean differences in plasma GFAP concentrations between groups with 95% bias-corrected bootstrap CIs

GFAP C9orf72 PS C9orf72 S GRN PS GRN S MAPT PS MAPT S
Controls21.1
(−18.8 to 66.5)
9.0
(−61.3 to 54.6)
14.2
(−2.4 to 38.3)
192.3**
(126.5 to 445.6)
−7.0
(−61.8 to 7.8)
12.7
(−33.3 to 90.4)
C9orf72 PS12.1
(−64.1 to 85.1)
−6.9
(−51.0 to 43.0)
171.2**
(88.5 to 433.7)
−28.1
(−83.3 to 8.0)
8.4
(−87.5 to 74.5)
C9orf72 S−5.2
(−79.4 to 39.4)
183.3**
(106.1 to 427.2)
−16.0
(−84.3 to 32.9)
−3.7
(−104.5 to 56.1)
GRN PS 178.1**
(114.3 to 365.2)
−21.2
(−78.3 to 1.5)
1.5
(−75.4 to 49.1)
GRN S199.3**
( 439.2 to – 124.9)
179.6**
( 348.1 to 99.8)
MAPT PS19.6
(−30.8 to 114.4)
  • Significant differences in bold: **p<0.01.

  • GFAP, glial fibrillary acidic protein; PS, presymptomatic; S, symptomatic.