Table 2

Stimulation of the post-commissural dorsal fornix in rodents and patients with epilepsy, along with main findings

StudyModelStimulation patternMain findings
William and Givens 2003RatsAcute single pulsesHippocampal theta reset
McNaughton et al 2006Rats, medial septum pharmacologically inactivatedAcute fixed thetaIncreases theta power, improves initial performance in Morris Water Maze (MWM)
Acute irregular thetaDoes not increase theta power, nor improves performance in MWM
Acute closed loop thetaIncreases theta power, improves performance in MWM a sustained way
Shirvalkar et al 2010Rats, medial septum pharmacologically inactivatedAcute thetaDoes not improve theta–gamma coupling in hippocampus nor memory performance
Acute 100 HzDoes not improve theta–gamma coupling in hippocampus nor memory performance
Acute TBSRestores theta-gamma coupling in hippocampus and memory performance in radial water maze
Hao et al 2015Mouse model of Rett syndromeChronic 100 HzImproves LTP and neurogenesis in hippocampus, and contextual fear memory
Miller et al 2015Patients with epilepsyAcute TBSImprovement in visuospatial memory
  • LTP, long-term potentiation; MWM, Morris water maze; TBS, theta burst stimulation.