Control group (those not taking dopamine medication but assessed at the same time points) (n=104) | Pre-antidopaminergic and post-antidopaminergic treatment group (n=90) | |
Number of visits | 4.4 (0.6) 4–6 | 4.3 (0.5) 4–6 |
Gender (m:f) | 52:48 | 41:49 |
ISCED | 3.8 (1.2) 1–6 | 3.5 (1.2) 2–6 |
Age | 52.6 (12) 28–83 | 53 (11.3) 26–79 |
CAG repeat length | 42.9 (4.9) 38–52 | 43.4 (2.6) 39–51 |
DBS | 388 (78.2) 167.5–589 | 392.9 (66.1) 202.5–567 |
TFC score Max score 13 | 10.1 (3.2) 0–13 | 9.2 (3.2) 0–13 |
Time since diagnosis (years) | 4.1 (4.2) 0–20 | 4 (4) 0–20 |
Motor score (UHDRS) Max score 124 | 28.1 (18.18) 5–95 | 31.3 (15.4) 7–80 |
Total chorea score (UHDRS) Max score 28 | 7.8 (4.9) 0–21 | 9.5* (5) 0–21 |
Irritability (PBA) Max score 32 | 1.8 (2.8) 0–13 | 4.3† (5.6) 0–24 |
Depression (PBA) Max score 48 | 2.7 (3.9) 0–18 | 4.2* (5.5) 0–23 |
Apathy (PBA) Max score 16 | 2 (3.7) 0–16 | 2.8 (4.1) 0–16 |
MMSE Max score 30 | 27.5 (2.6) 17–30 | 26.3 (2.9) 16–30 |
Composite cognitive z-score | 1.5 (5.4) −11.2 to 15.8 | 1.7† (4.8) 19.2–11.3 |
ISCED, The International Standard Classification of Education; CAG, cytosine-adenine-guanine; MMSE, Mini-Mental State Examination.
*Indicates a significant difference (p<0.005) when compared with the control non-antidopaminergic medication group.
†Indicates a significant difference (p<0.001) when compared with the control non-antidopaminergic medication group.
DBS, disease burden score; PBA, problems behavioural assessment; TFC, total functional capacity; UHDRS, Unified Huntington Disease Rating Scale.