Table 2

Relationship between NPTX2 and grey matter volume. Results were obtained through multiple linear regression with square-root transformed NPTX2 as dependent variable, adjusting for age, gender and study site. All grey matter volumes were corrected for total intracranial volume

All mutation carriers (n=126)Symptomatic mutation carriers (n=35)Presymptomatic mutation carriers (n=91)
Whole brain volume
 b (SE)1.07 (0.25)1.21 (0.42)0.58 (0.39)
 β0.5330.5850.215
 p<0.001*0.007*0.145
Frontal lobe
 b (SE)3.86 (0.83)4.40 (1.33)3.48 (1.44)
 β0.5160.6230.331
 p<0.001*0.003*0.018
Temporal lobe
 b (SE)4.01 (1.32)5.00 (2.27)0.67 (2.11)
 β0.3380.4480.039
 p0.003*0.0370.752
Parietal lobe
 b (SE)4.89 (1.77)5.51 (4.25)2.70 (2.18)
 β0.3230.3190.169
 p0.007*0.2080.218
Occipital lobe
 b (SE)1. 45 (1.77)-6.65 (4.03)3.10 (1.97)
 β0.086-0.3410.185
 p0.4120.1120.119
Cingulate gyrus
 b (SE)10.49 (5.27)14.72 (11.32)0.46 (7.27)
 β0.2050.2850.008
 p0.0490.2060.95
Insula
 b (SE)37.22 (8.69)69.21 (13.09)12.61 (13.16)
 β0.4820.7860.119
 p<0.001*<0.001*0.341
  • P values marked with an asterisk remained significant after Bonferroni correction. b indicates unstandardised regression coefficient. β indicates standardised regression coefficient.

  • NTPX, neuronal pentraxin.