Table 3

Common outcome domains and measures in functional neurological disorder intervention studies

Outcome domainCommonly used measures
Core symptomsCGI-I: patient-rated=9, clinician-rated=7, both=4
Seizure frequency/remission=30
Other physical symptomsPHQ-15/extended PHQ-15*=7
SCL-90 Somatic Symptom Scale=6
Psychological symptomsDepression: BDI/BDI-II=12, HAM-D=13
Anxiety: BAI=8, HAM-A=7
Depression and anxiety: HADS=14
Life impact: quality of life/disability/general functioningSF-36=22, SF-12=3
QoLIE-31=7, QoLIE-10=2
Health economics/cost–utilityHealthcare resource use=20 (CSRI=4)
QALYs (SF-36/EQ-5D-5L)=3
Illness beliefs/attributionsIPQ/modified IPQ=10
  • *Extended PHQ-15 (S29).

  • BAI, Beck Anxiety Inventory; BDI, Beck Depression Inventory; CGI-I, Clinical Global Impression–Improvement; CSRI, Client Service Receipt Inventory; DES, Dissociative Experiences Scale; GAF, Global Assesment of Functioning; HADS, Hospital Anxiety & Depression Scale; HAM-A, Hamilton Anxiety Rating Scale; HAM-D, Hamilton Depression Rating Scale; IPQ, Illness Perception Questionnaire; PHQ-15, Patient Health Questionnaire-15; PMDRS, Psychogenic Movement Disorder Rating Scale; QALY, quality-adjusted life years; QoLIE-10, Quality of Life in Epilepsy-10; QoLIE-31, Quality of Life in Epilepsy-31; SCL-90, Symptom Checklist-90; SF-12, 12-Item Short Form Health Survey; SF-36, 36-Item Short Form Health Survey; WSAS, Work and Social Adjustment Scale.