Table 3

Relationship between NPTX2 and disease severity scores, obtained through multiple linear regression with square-root transformed NPTX2 as dependent variable, adjusting for age, gender, study site and, in analyses of MMSE, TMT-B and letter fluency, years of education

All mutation carriersSymptomatic mutation carriersPresymptomatic mutation carriers
MMSE
 n1455095
 b (SE)1.21 (0.26)0.98 (0.29)1.58 (0.79)
 β0.4420.4670.23
 p<0.001*0.002*0.051
TMT-B
 n1253491
 b (SE)−0.04 (0.01)−0.02 (0.02)−0.09 (0.04)
 β−0.353−0.234−0.259
 p<0.001*<0.001*0.03
Phonemic verbal fluency
 n1323993
 b (SE)0.14 (0.05)0.15 (0.10)0.05 (0.08)
 β0.2550.250.076
 p0.009*0.1510.536
CDR plus FTD modules
 n1203387
 b (SE)−0.85 (0.19)−0.72 (0.24)−1.19 (1.67)
 β−0.435−0.479−0.078
 p<0.001*0.007*0.478
CBI-R
 n1194079
 b (SE)−0.13 (0.03)−0.10 (0.04)−0.02 (0.14)
 β−0.489−0.394−0.014
 p<0.001*0.017*0.906
  • P values are before multiple testing correction; p values marked with an asterisk remained significant after Bonferroni correction. b indicates unstandardised regression coefficient; β indicates standardised regression coefficient.

  • CBI-R, Revised Cambridge Behavioural Inventory; CDR, Clinical Dementia Rating scale; MMSE, Mini Mental State Examination; TMT-B, Trail Making Test part B.