Table 3

Association between DQB1*05:02–DRB1*16:02 haplotype and clinical features in paediatric-onset patients with MOGADs

Patients with haplotype n=10Controls n=41P value
Age, years, median (range)11 (3–16)10 (3–18)
Age of onset, years, median (range)4 (2–14)8 (2–13)
Inducement, n (%)
 Previous infection3 (30)15 (38)0.730
Phenotype at onset, n (%)*
 ON5 (50)20 (49)>0.999
 Myelitis2 (20)2 (5)0.168
 Encephalopathy5 (50)21 (51)>0.999
 Brainstem syndrome04 (10)0.573
 Others03 (7)>0.999
Initial EDSS, median (range)4.25 (2–8)3 (1–6.5)0.004
Baseline titre, median (range)320 (100–640)100 (100–1280)0.387
Patients with relapse, n (%)8 (80)15 (37)0.030
Relapse type, n (%)*
 ON9/16 (56)10/31 (32)0.131
 Myelitis2/16 (13)2/31 (7)0.597
 Encephalopathy6/16 (38)18/31 (58)0.227
 Brainstem syndrome04/31 (13)0.284
  • *Patients may exhibit multiple phenotypes simultaneously.

  • EDSS, Expanded Disability Status Scale; MOGADs, myelin oligodendrocyte glycoprotein-associated disorders; ON, optic neuritis.