Table 1

Candidate genes and SNPs and genotype frequencies

Gene symbolRs numberWild type>variant alleleGenotype frequencyHardy-Weinberg equilibrium (P value)
HTR1Ars6295C/GCC=0.23, GC=0.48, GG=0.290.73
HTR1Brs6296C/GCC=0.64, GC=0.29, GG=0.070.48
HTR2Ars6313G/AGG=0.42, AG=0.46, AA=0.120.85
rs6311C/TCC=0.82, TC=0.16, TT=0.010.58
TPH1rs1800532A/CAA=0.30, CA=0.42, AA=0.270.18
TPH2rs4570625G/TGG=0.53, TG=0.42, TT=0.040.36
SLC6A4* rs25531A/GS=0.44, LA=0.52, LG=0.040.64
CRHR1rs110402G/AGG=22, AG=31, AA=160.43
rs1876831C/TCC=50, TC=17, TT=20.70
CNR1rs1049353G/AGG=48, AG=18, AA=30.44
FAAHrs324420A/CCC=0.63; AC=0.30 AA=0.070.48
FKBP5rs9470080A/GAA=11, GA=34, GG=240.85
rs3800373C/ACC=9, AC=28, AA=320.47
rs1360780T/CTT=9, CT=32, CC=280.97
NR3C1rs10482672G/AGG=54, AG=14, AA=10.93
BDNFrs6265G/AGG=46, AG=20, AA=30.66
COMTrs4680G/AGG=19, AG=39, AA=110.22
SLC1A3rs2269272C/TCC=48, TC=20, TT=10.49
  • *SLC6A4 rs25531 was genotyped as part of the triallelic 5-HTTLPR locus (high activity LA allele; low transcriptional activity S allele, low transcriptional activity LG allele). Alleles were grouped as low activity (SS, S LG, LGLG) (0.23), intermediate activity (S LA, LALG) (0.49) and high activity (LALA) (0.28) variants.

  • BDNF, brain-derived neurotrophic factor; CNR1, cannabinoid receptor type 1; COMT, catechol-O-methyltransferase; CRHR1, corticotropin-releasing hormone receptor 1; FAAH, fatty acid amide hydrolase; FKBP5, FK506 binding protein 5; HTR1A, 5-Hydroxytryptamine Receptor 1A; HTR2A, 5-Hydroxytryptamine Receptor 2A; HTR1B, 5-Hydroxytryptamine Receptor 1B; NR3C1, nuclear receptor subfamily 3 group C member 1; TPH1, tryptophan hydroxylase 1; TPH2, tryptophan hydroxylase 2.