Table 4

Characteristics of participants in RUN DMC, stratified by median WMH scores

Low severity (n = 166)Moderate-high severity (n = 165)P
Age65.5 (6.7)72.6 (8.1)<0.001
Sex, female (%)66 (39.8)68 (41.2)0.875
Education0.009
Low (%)9 (5.4)21 (12.7)
Medium (%)88 (53.0)97 (58.8)
High (%)69 (41.6)47 (28.5)
Hypertension (%)122 (73.5)143 (86.7)0.004
Diabetes (%)20 (12.7)28 (17.5)0.305
Hypercholesterolaemia (%)70 (44.6)91 (56.9)0.038
Smoking0.029
Never (%)53 (31.9)42 (25.5)
Ex (%)85 (51.2)107 (64.8)
Current (%)28 (16.9)16 (9.7)
BMI, kg/m2 27.9 (4.4)27.8 (4.8)0.89
Dementia5 (3.0)28 (17.0)<0.001
Apathy25.5 (6.4)29.4 (9.3)<0.001
Depression14.5 (3.6)14.3 (4.7)0.714
MMSE28.6 (1.5)27.6 (2.4)<0.001
PS index−1.1 (0.7)−1.4 (0.7)<0.001
IADL7.9 (0.3)7.5 (1.3)<0.001
  • BMI, body mass index; IADL, Instrumental Activities of Daily Living; MMSE, Mini Mental State Examination; PS, processing speed; RUN DMC, Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort; WMH, White matter hyperintensity volume.