Table 4

Class II human leucocyte antigen haplotypes and clinical classification in 30 patients with anti-CASPR2 antibodies

Sex, age (years)GroupHaplotype/1Haplotype/2
DRB1DQB1DQA1DRB1DQB1DQA1
M, 62LE/− 11:01:01 03:01:0105:XX 11:01:01 03:01:0105:XX
M, 66LE/− 11:01:01 03:01:0105:XX 11:01:01 03:01:0105:XX
M, 69LE/− 11:01:01 03:01:0105:XX11:04:0103:01:0105:XX
M, 53LE/− 11:01:02 03:01:01XX03:01:0102:01:01XX
M, 66LE/− 11:01:01 03:01:0105:XX 11:01:01 03:01:0105:XX
M, 61LE/− 11:01:01 03:01:0105:05:0113:01:0106:03:0101:XX
M, 71LE/− 11:01:01 03:01:0105:XX 11:01:01 03:01:0105:XX
M, 72LE/−15:01:0106:02:0101:02:0104:01:0103:02:0103:01:01
M, 66LE/− 11:01:01 03:01:0105:XX13:01:0106:03:0101:03:01
M, 61LE/− 11:01:01 03:01:0105:XX04:05:0103:02:0103:XX
M, 71LE/+ 11:01:01 03:01:0105:XX08:02:0104:02:0104:01:01
M, 60LE/+ 11:01:01 03:01:0105:XX13:01:0106:03:0101:03:01
M, 72LE/+ 11:01:01 03:01:01XX11:02:0103:19:01XX
M, 69LE/+ 11:01:02 05:02:0101:02:0104:05:0102:XX03:XX
M, 68LE/+ 11:01:01 03:01:0105:XX07:01:0102:XX02:01:01
M, 62LE/+ 11:01:01 03:01:0105:XX07:01:0102:XX02:01:01
M, 57LE/+ 11:01:01 03:01:0105:XX 11:01:01 03:01:0105:XX
F, 58PNH/+16:01:0105:02:0101:0203:01:0102:01:0105:01:01
M, 48PNH/+04:01:0103:01:0103:XX04:04:0103:02:0103:XX
M, 60PNH/+ 11:01:01 03:01:0105:XX11:04:0103:01:0105:XX
M, 65PNH/+01:03:0103:01:0105:XX04:08:0103:01:0103:01:01
M, 41PNH/+16:01:0105:02:0101:0211:04:0103:01:0105:XX
M, 43PNH/+15:01:0106:02:0101:02:0103:01:0102:01:0105:01:01
M, 73PNH/+11:01:0103:01:0105:XX07:01:0102:XX02:01:01
M, 29PNH/+03:01:0102:XX05:01:0107:01:0102:01:0102:01:01
F, 37PNH/−04:05:0103:02:0103:XX13:01:0106:03:0101:03:01
M, 28PNH/−04:01:0103:02:0103:XX01:01:0105:01:0101:01:01
M, 39PNH/− 11:01:01 03:01:0105:XX07:01:0102:XX02:01:01
M, 58*PNH/−01:01:0105:01:0101:01:0101:03:0105:01:0101:01:01
M, 68*PNH/− 11:01:01 03:01:0105:XX07:01:0102:XX02:01:01
  • Alleles are reported at six-digit level, unless it was not technically possible (XX). DRB1*11:01 is highlighted in bold. *PNH/− indicates patients presenting also with limbic features.

  • CASPR2-Abs, anti-CASPR2 antibodies; F, Female; HLA, human leukocyteantigen; LE, limbic encephalitis; M, male; PNH, peripheral nerve hyperexcitability.