Table 1

Characteristics of the dementia risk scores with comparisons of the categorisations used in the original CAIDE study3 and the current study (modified from7)

CAIDE categoriesCAIDE in
FTC
CAIDE score
(max 15)*
Educational-occupational categoriesSelf-report score (max 25)
Age, years<47<470Education, yearsLess than 60
47–5347–53364
>53>5347–86
96
Education, years≥10≥10010–117
7−97–9212 or more11
0−60−63Work statusNot working0
Home maker1
GenderFemaleFemale0Working/studying1
MaleMale1Nature of workVery monotonous0
Somewhat monotonous/somewhat variable2
Midlife high BPSystolic BP ≤140 mm HgBP found to be normal0Very variable2
Systolic BP >140 mm HgBP found to be high/slightly elevated2Work environmentOutdoors or both outdoors and indoors0
Indoors1
Midlife BMI≤30 kg/m2≤30 kg/m20Physical loading of workHeavy manual labour0
>30 kg/m2>30 kg/m22Manual labour: standing and walking+lifting and carrying1
Manual labour: standing and walking1
Midlife cholesterol level≤6.5 mmol/LCholesterol found normal0Mainly sitting, very little physical activity required1
>6.5 mmol/LCholesterol found high2Age in years≥600
54–594
Midlife physical activityActive (physical activity ≥2 times/week, lasting at least 20–30 min per time, causing sweating and breathlessness)Active (physical activity at least six times/month, at least 30 min mean duration, intensity corresponding at least vigorous walking)047–536
40–468
≤399
Inactive†Inactive†1
  • Educational-occupational score is based on Vuoksimaa et al.10

  • *The original CAIDE score encompasses a scoring system with or without APOE allele status. We used the scoring system without APOE allele status because our MZ within-family analyses are naturally matched for the APOE allele status.

  • †Physically inactive means that the participant does not fulfil the criteria of physically active.

  • BMI, body mass index; BP, blood pressure; CAIDE, Cardiovascular Risk Factors, Aging and Dementia; CR, cognitive reserve; FTC, Finnish Twin Cohort.