Table 1

Characteristics of the dementia risk scores with comparisons of the categorisations used in the original CAIDE study3 and the current study (modified from7)

CAIDE categoriesCAIDE in
CAIDE score
(max 15)*
Educational-occupational categoriesSelf-report score (max 25)
Age, years<47<470Education, yearsLess than 60
Education, years≥10≥10010–117
7−97–9212 or more11
0−60−63Work statusNot working0
Home maker1
MaleMale1Nature of workVery monotonous0
Somewhat monotonous/somewhat variable2
Midlife high BPSystolic BP ≤140 mm HgBP found to be normal0Very variable2
Systolic BP >140 mm HgBP found to be high/slightly elevated2Work environmentOutdoors or both outdoors and indoors0
Midlife BMI≤30 kg/m2≤30 kg/m20Physical loading of workHeavy manual labour0
>30 kg/m2>30 kg/m22Manual labour: standing and walking+lifting and carrying1
Manual labour: standing and walking1
Midlife cholesterol level≤6.5 mmol/LCholesterol found normal0Mainly sitting, very little physical activity required1
>6.5 mmol/LCholesterol found high2Age in years≥600
Midlife physical activityActive (physical activity ≥2 times/week, lasting at least 20–30 min per time, causing sweating and breathlessness)Active (physical activity at least six times/month, at least 30 min mean duration, intensity corresponding at least vigorous walking)047–536
  • Educational-occupational score is based on Vuoksimaa et al.10

  • *The original CAIDE score encompasses a scoring system with or without APOE allele status. We used the scoring system without APOE allele status because our MZ within-family analyses are naturally matched for the APOE allele status.

  • †Physically inactive means that the participant does not fulfil the criteria of physically active.

  • BMI, body mass index; BP, blood pressure; CAIDE, Cardiovascular Risk Factors, Aging and Dementia; CR, cognitive reserve; FTC, Finnish Twin Cohort.