Table 1

: Main inclusions and exclusions criteria

Inclusion criteriaExclusion criteria
OCD defined by DSM-IVYesYes: bipolar disorder, schizophrenic disorder; current substance abuse or dependence (except nicotine)
Cluster A/B personality disordersNAYes
Recent severe depressionNAYes
  • MADRS score >20

  • Risk of suicide (MADRS item-10 score >2)

MedicationsFailure of three serotonin reuptake inhibitors including clomipramine after a minimum of 12 weeks of adequate treatment and two augmentation strategiesNA
PsychotherapyFailure of cognitive behavioural therapy conducted during at least 1 year with two therapistsNA
  • CGI, Clinical Global Impression; DSM-IV, Diagnostic And Statistical Manual OF mental Disorders- 4 th edition; GAF, Global Assessment Functioning; MADRS, Montgomery-Asberg Depression Rating Scale; NA, not applicable; OCD, obsessive–compulsive disorder; YBOCS, Yale and Brown Obsessive–Compulsive Scale .