: Main inclusions and exclusions criteria
| Inclusion criteria | Exclusion criteria | |
| OCD defined by DSM-IV | Yes | Yes: bipolar disorder, schizophrenic disorder; current substance abuse or dependence (except nicotine) |
| Cluster A/B personality disorders | NA | Yes |
| Recent severe depression | NA | Yes
|
| Age | >18 | NA |
| YBOCS | >25 | NA |
| GAF | <45 | NA |
| CGI | >4 | NA |
| Medications | Failure of three serotonin reuptake inhibitors including clomipramine after a minimum of 12 weeks of adequate treatment and two augmentation strategies | NA |
| Psychotherapy | Failure of cognitive behavioural therapy conducted during at least 1 year with two therapists | NA |
CGI, Clinical Global Impression; DSM-IV, Diagnostic And Statistical Manual OF mental Disorders- 4 th edition; GAF, Global Assessment Functioning; MADRS, Montgomery-Asberg Depression Rating Scale; NA, not applicable; OCD, obsessive–compulsive disorder; YBOCS, Yale and Brown Obsessive–Compulsive Scale .