Relationship between sNfL levels and basal characteristics
| Basal characteristics (n=98) | sNfL (pg/mL); GeoMean (GeoMean 95% CI), CV% | P value | |
| Age, mean±SD | 57.35±16.6 | – | 0.071 |
| Gender, n (%) | |||
| Male | 56 (57.1) | 52.48 (31.62 to 79.43), 41.5 | 0.625 |
| Female | 42 (42.9) | 60.26 (39.81 to 100), 41.8 | |
| Infectious antecedent, n (%) | |||
| Diarrhoea | 24 (24.5) | 134.90 (63.10 to 251.19), 36.6 | 0.016 |
| Respiratory infection | 43 (43.9) | 38.02 (25.12 to 63.10), 42.6 | |
| None | 31 (31.6) | 47.86 (28.35 to 81.50), 39.3 | |
| Evolution time (days), median (IQR) | 4 (3–6) | – | 0.413 |
| Initial GDS, median (IQR) | 3 (2–4) | ||
| 1, n (%) | 4 (4.1) | 6.17 (3.98 to 10), 25.4 | 0.005 |
| 2, n (%) | 28 (28.6) | 35.48 (19.95 to 63.10), 46.1 | |
| 3, n (%) | 19 (19.4) | 64.56 (31.62 to 125.89), 36.5 | |
| 4, n (%) | 45 (25.9) | 77.62 (59.12 to 125.89), 35.7 | |
| 5, n (%) | 2 (2) | 375.83; 53.5 | |
| MRC sumscore, median (IQR) | |||
| Baseline | 50 (42–56) | – | <0.001 |
| At 1 week | 51 (39–58) | – | 0.073 |
| GBS variants, n (%) | |||
| Sensorimotor | 65 (66.3) | 38.02 (25.12 to 50.12); 37 | 0.009 |
| Pure motor | 18 (18.4) | 162.18 (79.43 to 398.11); 34.7 | |
| Pure sensory | 4 (4.1) | 26.30 (1.26 to 501.19); 91.6 | |
| MFS Ataxic | 10 (10.2) 1 (1) | 95.50 (31.62 to 316.23); 42.3 338.84 | |
| EMG classification, n (%) | |||
| AIDP | 58 (59.2) | 33.88 (25.12 to 50.12), 37.7 | 0.008 |
| AMAN | 12 (12.2) | 199.53 (79.43 to 501.19), 28.5 | |
| AMSAN | 7 (7.1) | 107.15 (25.12 to 501.19), 44 | |
| Equivocal | 14 (14.3) | 104.7 (39.81 to 316.22), 43 | |
| Normal | 7 (7.1) | 53.70 (12.59 to 251.19), 50 | |
| Treatment, n (%) | |||
| No | 6 (6.1) | 7.59 (3.98 to 12.59), 37.5 | 0.009 |
| IVIg | 76 (77.6) | 72.44 (50.12 to 100.43), 39.1 | |
| IVIg x2 | 5 (5.1) | 32.36 (15.85 to 79.43), 27 | |
| IVIg+PLEX | 10 (10.2) | 30.90 (12.59 to 79.43), 41.8 | |
| PLEX | 1 (1) | 117.49 | |
AIDP, acute inflammatory demyelinating polyneuropathy; AMAN, acute motor axonal neuropathy; AMSAN, acute motor-sensory axonal neuropathy; CV, coefficient of variation; EMG, Electromyography; GBS, Guillain-Barré Syndrome; GDS, Guillain-Barré Syndrome Disability Score; GeoMean, geometric mean; IVIg, intravenous immunoglobulin; MFS, Miller Fisher Syndrome; MRC, Medical Research Council; PLEX, plasma exchange; sNfL, serum neurofilament light chain.