Cause-specific hazard models: univariate associations between MRI characteristics and functional decline
| Baseline values | First transition to mRS 4/5 | |||
| Events | CSHR (95% CI) | P value | ||
| WMH score, median (IQR) | 2 (1–2) | 32 | 1.62 (1.11 to 2.34) | 0.011 |
| Lacunes | 55/144 (38.2) | 16 | 1.88 (0.94 to 3.75) | 0.075 |
| Cerebral atrophy score, median (IQR) | 1 (1–2) | 32 | 2.29 (1.45 to 3.62) | <0.001 |
| CMBs | ||||
| None | 63/144 (43.8) | 6 | 1.00 (ref) | 0.003 |
| CMBs strictly deep | 13/144 (9.0) | 1 | 0.87 (0.10 to 7.23) | |
| CMBs strictly lobar | 24/144 (16.7) | 9 | 5.45 (1.93 to 15.33) | |
| CMBs mixed | 44/144 (30.6) | 16 | 4.35 (1.70 to 11.13) | |
| cSS | ||||
| None | 117/143 (81.8) | 24 | 1.00 (ref) | 0.088 |
| cSS focal | 19/143 (13.3) | 7 | 2.57 (1.10 to 6.02) | |
| cSS disseminated | 7/143 (4.9) | 1 | 0.83 (0.11 to 6.13) | |
Data are n (%) or median (IQR) unless otherwise indicated.
CMBs, cerebral microbleeds; CSHR, cause-specific HR; cSS, cortical superficial siderosis; mRS, modified Rankin Scale; WMH, white matter hyperintensities.