Table 1

Demographic data and laboratory assessment

OND (n=85)Typical CIDP (n=35)Atypical CIDP (n=18)AIDP (n=12)Axonal GBS (n=3)
Gender (M/F, n)48/3727/816/26/62/1
Age (y) (mean±SD)58±1864±13*68±1167±1174±7
CSF protein (gr/L)0.38±0.12 (0.35–0.42)0.92±0.59**** (0.72–1.13)0.71±0.30* (0.56–0.86)0.68±0.31 (0.47–0.90)0.53±0.48 (0.19–0.88)
QAlb6.00±3.00 (5.24–8.70)16.41±12.11**** (12.11–20.70)10.7±4.0 (8.63–12.77)13.00±5.76* (9.37–16.70)6.85±4.00 (3.75–11.00)
QIgG3.14±1.26 (2.78–3.49)9.27±7.56**** (6.59–11.96)5.25±2.00 (4.17–6.33)9.00±5.55*** (5.55–12.61)3.14±3.40 (1.00–7.15)
Cells (cells/µL)1.38±2.38 (0.70–2.06)1.64±1.71 (1.05–2.23)1.22±1.07 (0.69–1.76)1.18±1.06 (0.50–1.86)0.53±0.40 (0.30–1.00)
OCBs CSF=S (n, %)20/51 (39)20/31 (64)9/14 (64)6/10 (60)2/3 (66)
  • According to the literature, CIDP, independently from clinical subtype, showed a male predominance with prevalence in the elderly.2 19 The typical albuminocytologic dissociation was reported for CIDP and GBS. Moreover, in up to 60% of patients with CIDP and AIDP, we found a mirror OCB pattern on isoelectric focusing (OCBs that were identical in CSF and serum; no intrathecal IgG production).

  • *Data were expressed as mean±SD and CI (values between parentheses), unless otherwise specified. Holm-Sidak multiple comparison test after one-way analysis of variance was used for statistical comparison of multiple groups: *p<0.05; ***p<0.001; ****p<0.0001.

  • AIDP, acute inflammatory demyelinating polyradiculoneuropathy; CIDP, chronic inflammatory demyelinating polyradiculoneuropathy; CSF, cerebrospinal fluid; GBS, Guillain-Barré syndrome; M/F, male/female; OCB, oligoclonal band; OCBs CSF=S, oligoclonal IgG bands identical in CSF and serum; OND, other neurological diseases; QAlb, CSF to serum albumin concentration quotient; QIgG, CSF to serum IgG concentration quotient.