Examples of multicentre dementia studies including an advanced imaging component
Study name | Acronym | No recruited | Participant characteristics | No of sites |
Alzheimer’s Disease Neuroimaging Initiative56 | ADNI | 800 (ADNI1)+ 200 (ADNI GO)+ 650 (ADNI2) | AD/MCI, controls | 57 (USA+Canada) |
Parkinson’s Progression Markers Initiative59 | PPMI | 400 | Parkinson’s disease | 30 (12 countries) |
200 | Controls | |||
Longitudinal Frontotemporal Lobar Degeneration6 w271 | ARTFL-LEFFTDS | 1560 | FTD | 14 (USA+Canada) |
Genetic Frontotemporal dementia Initiative5 | GENFI | 1100 | Familial FTD | 27 (11 countries) |
Dominantly Inherited Alzheimer Network Trial7 w72 | DIAN-TU | 490 | Familial AD | 42 (17 countries) |
Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageingw272 | AIBL | 1000 | Ageing individuals, AD/MCI | 6 (Australia) |
DZNE Longitudinal Cognitive Impairment and Dementia Study study60 | DELCODE | 1000 | Predementia | 8 (Germany) |
Longitudinal Early-Onset Alzheimer’s Disease Studyw273 | LEADS | 600 | AD aged between 40 and 64 | 14 (USA) |
4 Repeat Tauopathy Neuroimaging Initiativew274 | 4RTNI | 110 | PSP or CBD | 2 (USA) |
Progressive Supranuclear Palsy Corticobasal Syndrome Multiple System Atrophy Longitudinal Studyw275 | PROSPECT | 900 | PSP, CBS, atypical Parkinsonism | 7 (UK) |