Table 5

Three-tier algorithm of oral preventive treatments for short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing and short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms

Medications (maximum dose)
First-line treatment

  • Lamotrigine (up to 700 mg/day)

Second-line treatments

  • Oxcarbazepine (up to 2400 mg/day)

  • Duloxetine (up to 120 mg/day)

  • Carbamazepine (up to 1600 mg/day)

  • Topiramate (up to 800 mg/day)

Third-line treatments

  • Gabapentin (up to 4800 mg/day)

  • Pregabalin (up to 600 mg/day)

  • Lacosamide (up to 400 mg/day)

  • Mexiletine (up to 1200 mg/day)