Baseline characteristics of patients with or without ICAS in OXVASC and CUHK-SR
| Characteristics | OXVASC (n=1287) | CUHK-SR (n=691) | ||||
| Any ICAS (n=257) | No ICAS (n=1030) | P value | Any ICAS (n=297) | No ICAS (n=394) | P value | |
| Age, years | 75 (12.2) | 68 (13.8) | <0.001 | 68 (12.3) | 64 (11.9) | <0.001 |
| Age ≥70 years | 201 (78.2) | 514 (49.9) | <0.001 | 146 (49.2) | 133 (33.8) | <0.001 |
| Male sex | 141 (54.9) | 526 (51.1) | 0.276 | 184 (62.0) | 257 (65.2) | 0.375 |
| Ever-smoker | 138 (53.7) | 550 (53.4) | 0.943 | 116 (39.1) | 154 (39.1) | 0.994 |
| Male smoker | 90 (63.8) | 341 (65.0) | 0.804 | 76 (41.3) | 98 (38.1) | 0.502 |
| Female smoker | 48 (41.4) | 209 (41.5) | 0.986 | 40 (35.4) | 56 (40.9) | 0.375 |
| History of hypertension | 180 (70.0) | 527 (51.2) | <0.001 | 219 (73.7) | 234 (59.4) | <0.001 |
| History of diabetes | 49 (19.1) | 120 (11.7) | 0.002 | 101 (34.0) | 80 (20.3) | <0.001 |
| History of dyslipidaemia | 111 (43.2) | 325 (31.6) | <0.001 | 173 (58.2) | 181 (45.9) | 0.001 |
| Atrial fibrillation* | 59 (23.0) | 132 (12.8) | <0.001 | 30 (10.1) | 48 (12.2) | 0.392 |
| History of ischaemic stroke or TIA | 59 (23.0) | 133 (12.9) | <0.001 | 77 (25.9) | 67 (17.0) | 0.004 |
| History of ischaemic heart disease | 59 (23.0) | 107 (10.4) | <0.001 | 28 (9.4) | 26 (6.6) | 0.170 |
| Event type | 0.054 | 0.814 | ||||
| TIA | 155 (60.3) | 687 (66.7) | 88 (29.6) | 120 (30.5) | ||
| Minor stroke | 102 (39.7) | 343 (33.3) | 209 (70.4) | 274 (69.5) | ||
Values are mean (SD) or median (IQR) or number (%); Student’s t-tests were used for comparison of continuous variables and χ2 tests for categorical variables.
*History of atrial fibrillation and newly diagnosed atrial fibrillation after the index stroke or TIA.
CUHK-SR, the Chinese University of Hong Kong Stroke Registry; ICAS, intracranial atherosclerotic stenosis; OXVASC, Oxford Vascular Study; TIA, transient ischaemic attack.