Table 4

Estimate of HR for neuropsychological scores after joint longitudinal and time to event modelling

VariableHR (95% CI)
ECAS total0.88 (0.73 to 1.06)
ECAS ALS Specific0.65 (0.55 to 0.77)*
ECAS ALS-non-specific0.99 (0.84 to 1.16)
Reading the mind in the eyes1.17 (0.89 to 1.64)
Verbal fluency (unrestricted)0.93 (0.85 to 1.02)
Verbal fluency (restricted)1.04 (0.99 to 1.25)
CWIT inhibition1.09 (0.89 to 1.32)
CWIT switching0.99 (0.97 to 1.01)
Boston naming test0.99 (0.86 to 1.17)
RAVLT total0.99 (0.92 to 0.99)*
RAVLT delayed0.81 (0.55 to 1.02)
Logical Memory immediate1.80 (1.17 to 3.07)*
Logical memory delayed1.39 (0.57 to 2.68)
  • *P<0.001.

  • ALS, amyotrophic lateral sclerosis; CWIT, Colour-Word Interference Test; ECAS, Edinburgh cognitive and behavioural ALS screen; RAVLT, Rey Auditory Verbal Learning Test.