Distribution of FALS and clinical characteristics considering the number of generations with ALS
| MonoG (49) | BiG (152) | MultiG (34) | P value | |
| No of cases | ||||
| N=2 | 42 (85.7%) | 105 (69.1%) | ||
| N≥3 (%) | 7 (14.3%) | 47 (30.9%) | 34 (100.0%) | |
| Age of onset in the last generation | <0.0001 | |||
| Mean (years) | 63.6±10.2 | 57.3±11.7 | 50.2±11.5 | |
| n | 48 | 147 | 34 | |
| Site of onset | 0.59 | |||
| Bulbar (%) | 24.5 | 28.8 | 18.2 | |
| UL (%) | 34.7 | 29.5 | 27.3 | |
| LL (%) | 40.8 | 41.8 | 54.5 | |
| Duration of the disease | 0.84 | |||
| Median (months) | 30.3±34.4 | 30.1±33.8 | 30.0±62.1 | |
| Range | 7.0–179.2 | 4.0–209.2 | 5.9–221.2 | |
| n | 27 | 99 | 23 |
2: with two cases, ≥3: FALS with at least three ALS cases.
ALS, amyotrophic lateral sclerosis; BiG, Two generations with ALS cases; FALS, familial amyotrophic lateral sclerosis; MonoG, One generation with ALS cases; MultiG, at least 3three generations with ALS cases.