Longitudinal analysis
| Baseline marker prediction | ||||||||||
| Dementia conversion (n=19) | Decline in Global | Decline in PS | ||||||||
| β (SE) | P value | HR (95% CI) | AUC | β (SE) | P value | Adj. R | β (SE) | P value | Adj. R | |
| Serum NfL (pg/mL) (log 10) | 0.516 (0.178) | 0.004 | 1.676 (1.183 to 2.373) | 0.775 | −0.335 (0.094) | 0.001 | 0.353 | −0.277 (0.114) | 0.017 | 0.050 |
| MDPH (mm2/s) | −0.848 (0.265) | 0.001 | 0.428 (0.255 to 0.719) | 0.791 | 0.148 (0.106) | 0.169 | 0.265 | 0.139 (0.123) | 0.262 | −0.006 |
| PSMD (mm2/s) | 0.507 (0.155) | 0.001 | 1.661 (1.225 to 2.252) | 0.758 | −0.215 (0.098) | 0.032 | 0.290 | −0.143 (0.116) | 0.224 | −0.003 |
| Serum NfL (pg /mL) (log10) indep. MDPH (mm2/s) | 0.369 (0.179) | 0.040 | 1.446 (1.017 to 2.055) | 0.804 | ||||||
| Serum NfL (pg /mL) (log10) indep. PSMD (mm2/s) | −0.303 (0.095) | 0.002 | 0.365 | |||||||
DTI and NfL baseline markers predicting cognitive decline and dementia conversion.
Values show standardised regression coefficients: β and SEs for predictor variables in regression models of dementia conversion and decline in cognition. Significant at p value <0.05.
Adj R2, adjusted explained variance; AUC, area under the curve; DTI, diffusion tensor imaging; Global, global cognition; MDPH, mean diffusivity normalised peak height; NfL, neurofilament light chain; PS, processing speed; PSMD, peak width of skeletonised mean diffusivity.