Change in lacunes | Change in CMB | Change in WMH | Change in NBV | |

Serum NfL baseline (pg/mL) (log10) | 0.643 (0.319), p= 0.044,AUC=0.773 | 0.831 (0.320), p= 0.010,AUC=0.822 | 0.107 (0.094), p=0.257 | −0.234 (0.098), p= 0.019,Adj. R ^{2}
=0.227 |

Serum NfL change (pg/mL) | −0.083 (0.240), p=0.730 | 0.313 (0.240), p=0.193 | 0.124 (0.108), p=0.255 | 0.030 (0.108), p=0.779 |

Values show standardised regression coefficients β and SEs for predictor variables in regression models of change in imaging marker. Significant at p<0.05.

Adj R

^{2}, adjusted explained variance; AUC, area under the curve; CMB, cerebral microbleeds; Lacune, lacune count; NBV, normalised brain volume; NfL, serum neurofilament light chain; WMH, white matter hyperintensity lesion load.