The association between baseline and change in NfL marker and change in MRI markers over 3 years
| Change in lacunes | Change in CMB | Change in WMH | Change in NBV | |
| Serum NfL baseline (pg/mL) (log10) | 0.643 (0.319), p=0.044, AUC=0.773 | 0.831 (0.320), p=0.010, AUC=0.822 | 0.107 (0.094), p=0.257 | −0.234 (0.098), p=0.019, Adj. R2 =0.227 |
| Serum NfL change (pg/mL) | −0.083 (0.240), p=0.730 | 0.313 (0.240), p=0.193 | 0.124 (0.108), p=0.255 | 0.030 (0.108), p=0.779 |
Values show standardised regression coefficients β and SEs for predictor variables in regression models of change in imaging marker. Significant at p<0.05.
Adj R2, adjusted explained variance; AUC, area under the curve; CMB, cerebral microbleeds; Lacune, lacune count; NBV, normalised brain volume; NfL, serum neurofilament light chain; WMH, white matter hyperintensity lesion load.