Cross-sectional regression between DTI and/or NfL and cognition or disability
| Regression on cognition with single marker | Regression on cognition with multiple markers | Regression on disability | ||||||||||||
| Global | EF | PS | Global | EF | PS | mRS score | ||||||||
| β (SE) | Adj. R | β (SE) | Adj. R | β (SE) | Adj. R | β (SE) | Adj. R | β (SE) | Adj. R | β (SE) | Adj. R | β (SE) | HL R2 | |
| Serum NfL (pg/mL) (log 10) | −0.201 (0.072), p=0.006 | 0.459 | −0.155 (0.074), p=0.038 | 0.429 | −0.244 (0.082), p=0.004 | 0.288 | −0.118 (0.075), p=0.119 | 0.510 | −0.086 (0.080), p=0.284 | 0.450 | −0.187 (0.086), p=0.031 | 0.3660 | 0.279 (0.079), p=0.0004 | 0.1109 |
| MDPH (mm2/s) | 0.290 (0.071), p=8.42e−05 | 0.503 | 0.221 (0.075), p=0.004 | 0.449 | 0.330 (0.082), p=0.0001 | 0.342 | 0.255 (0.074), p=0.001 | 0.1951 (0.079), p=0.015 | 0.273 (0.084), p=0.002 | |||||
| PSMD (mm2/s) | −0.277 (0.067), p=7.23e−05 | 0.506 | −0.227 (0.070), p=0.002 | 0.462 | −0.322 (0.078), p=6.70e−05 | 0.344 | ||||||||
Significant at p<0.05.
Values show standardised regression coefficients β and SEs for predictor variables in regression models.
Adj R2, adjusted explained variance; DTI, diffusion tensor imaging; EF, executive function; Global, global cognition; HL R2, Hosmer and Lemeshow’s R2; MDPH, mean diffusivity normalised peak height; mRS score, modified rankin scale; NfL, neurofilament light chain; PS, processing speed; PSMD, peak width of skeletonised mean diffusivity.