Table 4

Total events, annualised event rate and univariable and multivariable association of presence/absence and severity of small vessel disease (SVD) burden and intracerebral haemorrhage and recurrent ischaemic stroke

		Follow-up time	Events	Annual event rate in %/year	Univariable		Multivariable 1*		Multivariable 2
		Follow-up time	Events	Annual event rate in %/year	HR	P value	HR	P value	HR	P value
*Intracerebral haemorrhage*
Severity of SVD	None/low (0)	1586	1	0.06 (0.00–0.35)	1 (ref)		1 (ref)
	Medium (1–2)	1535	6	0.39 (0.14–0.85)	4.8 (1.9–12.0)	0.001	5.0 (1.9–12.2)	0.001	4.6 (1.8–11.8)	0.001
	High (3–4)	245	4	1.63 (0.45–4.13)	4.8 (1.9–12.0)	0.001	5.0 (1.9–12.2)	0.001	4.6 (1.8–11.8)	0.001
*Recurrent ischaemic stroke*
Severity of SVD	None/low (0)	1586	17	1.07 (0.63–1.71)	1 (ref)		1 (ref)		1 (ref)
	Medium (1–2)	1535	32	2.08 (1.43–2.93)	1.7 (1.1–2.5)	0.010	1.5 (1.0–2.3)	0.049	1.5 (1.0–2.2)	0.075
	High (3–4)	245	7	2.86 (1.16–5.80)	1.7 (1.1–2.5)	0.010	1.5 (1.0–2.3)	0.049	1.5 (1.0–2.2)	0.075

*Multivariate model 1: HAS-BLED Score dichotomised in two categories: low risk (score 0–2) and high risk (score ≥3) for intracerebral haemorrhage and for CHA₂DS₂-VASc Score dichotomised in two categories: medium risk (score 2–4) and high risk (≥5) for recurrent ischaemic stroke.
Multivariate model 2: age and history of hypertension.