Distribution of different markers of small vessel disease on CT and MRI in patients with intracerebral haemorrhage comparing patients with prior anticoagulation therapy and those without
| CT cohort | ||||
| Prior anticoagulation therapy (n=421) | No prior anticoagulation therapy (n=609) | P value | ||
| Leukoaraiosis (van Swieten Score) | ||||
| Anterior region | 0 | 221 (52.5%) | 365 (59.9%) | 0.059 |
| 1 | 120 (28.5%) | 149 (24.5%) | ||
| 2 | 80 (19.0%) | 95 (15.6%) | ||
| Posterior region | 0 | 223 (53.0%) | 373 (61.2%) | 0.023 |
| 1 | 77 (18.3%) | 84 (13.8%) | ||
| 2 | 121 (28.7%) | 152 (25.0%) | ||
| Lacunes | ||||
| Number of lacunes | None | 385 (91.5%) | 545 (89.5%) | 0.373 |
| 1 lacuna | 25 (5.9%) | 50 (8.2%) | ||
| ≥1 lacunes | 11 (2.6%) | 14 (2.3%) | ||
| Atrophy | ||||
| Cortical atrophy | Absent | 25 (5.9%) | 137 (22.5%) | <0.001 |
| Moderate | 299 (71.0%) | 371 (60.9%) | ||
| Severe | 97 (23.0%) | 101 (16.6%) | ||
| Deep atrophy | Absent | 76 (18.1%) | 190 (31.2%) | <0.001 |
| Moderate | 228 (54.2%) | 302 (49.6%) | ||
| Severe | 117 (27.8%) | 117 (19.2%) | ||
| MRI cohort | ||||
| Prior anticoagulation therapy (n=61) | No prior anticoagulation therapy (n=175) | |||
| White matter hyperintensities (Fazekas Scale) | ||||
| Periventricular white matter | 0 | 1 (1.6%) | 12 (7.1%) | 0.065 |
| 1 | 19 (31.2%) | 73 (43.2%) | ||
| 2 | 28 (45.9%) | 63 (37.3%) | ||
| 3 | 12 (21.3%) | 21 (12.4%) | ||
| Deep white matter | 0 | 19 (31.2) | 85 (50.3%) | 0.008 |
| 1 | 16 (26.3%) | 38 (22.5%) | ||
| 2 | 14 (23.0%) | 35 (20.7%) | ||
| 3 | 12 (19.7%) | 11 (6.5%) | ||
| Lacunes | ||||
| Number of lacunes | No | 46 (79.3%) | 124 (77.0%) | 0.862 |
| 1 | 8 (13.8%) | 27 (16.8%) | ||
| ≥2 | 4 (6.9%) | 10 (6.2%) | ||
| Atrophy | ||||
| Global cortical atrophy | Absent | 19 (31.2%) | 99 (57.9%) | 0.001 |
| Moderate | 30 (49.2%) | 48 (28.1%) | ||
| Severe | 12 (19.7%) | 24 (14.0%) | ||
| Medial temporal atrophy | Absent | 10 (21.7%) | 38 (27.3%) | 0.429 |
| Moderate | 20 (43.5%) | 66 (47.5%) | ||
| Severe | 16 (34.8%) | 35 (25.2%) | ||
| Cerebral microbleeds | ||||
| Number | None | 26 (42.6%) | 94 (53.7%) | 0.326 |
| 1 | 7 (11.5%) | 17 (9.7%) | ||
| ≥2 | 28 (45.9%) | 64 (36.6%) | ||
| Cortical superficial siderosis | ||||
| None | 45 (88.2%) | 134 (90.5%) | 0.889 | |
| Focal | 4 (7.8%) | 9 (6.1%) | ||
| Disseminated | 2 (3.9%) | 5 (3.4%) | ||
| Perivascular spaces | ||||
| Centrum semiovale | None | 5 (8.2%) | 14 (8.2%) | 0.928 |
| Moderate | 31 (50.8%) | 91 (53.5%) | ||
| Severe | 25 (41.0%) | 65 (38.2%) | ||
| Basal ganglia | None | 7 (11.5%) | 27 (15.9%) | 0.001 |
| Moderate | 37 (60.7%) | 128 (75.3%) | ||
| Severe | 17 (27.9%) | 15 (8.8%) | ||