Characteristics of participants with the behavioural variant of Alzheimer’s disease (presented individually) and participants with typical Alzheimer’s disease (presented as a group) in the positron emission tomography study
| ADC | UCSF | BioFINDER | ||||||||
| bvAD1 | bvAD2 | Typical AD | bvAD3 | bvAD4 | bvAD5 | Typical AD | bvAD6 | bvAD7 | Typical AD | |
| n | 55 | 60 | 90 | |||||||
| Age | 73 | 62 | 65.7 (7.7) | 59 | 60 | 80 | 64.5 (8.8) | 80 | 70 | 73.1 (6.6) |
| Sex (% male) | m | m | 49% | m | m | m | 42% | f | m | 54% |
| Education (years) | 13 | 13 | 12.2 (3.1)a | 16 | 16 | 19 | 17.3 (3.1)c | 7 | 9 | 12.2 (4.9)f |
| MMSE | 17 | 22 | 23.2 (3.9) | 24 | 21 | 19 | 22.1 (6.5)d | 26 | 23 | 20.2 (4.1)g |
| APOE (% ε4 pos.) | ε3ε3 | ε3ε3 | 79%b | ε3ε3 | ε3ε4 | – | 58%e | ε3ε4 | ε3ε4 | 73%h |
| bvFTD criteria | ||||||||||
| Disinhibition | Y | N | Y | Y | N | Y | Y | |||
| Apathy | Y | Y | Y | N | Y | Y | Y | |||
| Loss of empathy | Y | N | N | N | Y | Y | N | |||
| Compulsiveness | N | Y | Y | Y | N | N | N | |||
| Hyperorality | Y | Y | N | N | N | N | Y | |||
| Dysexecutive | N | N | N | N | N | Y | N | |||
| n | 4 | 3 | 3 | 2 | 2 | 4 | 3 | |||
| Tau SUVR | ||||||||||
| Entorhinal | 1.27 | 1.81 | 1.49 (0.25) | 1.53 | 1.49 | 1.89 | 1.73 (0.35) | 1.59 | 1.91 | 1.98 (0.42) |
| Temporoparietal | 1.56 | 1.80 | 1.58 (0.40) | 1.67 | 1.74 | 1.76 | 1.94 (0.56) | 1.40 | 2.28 | 1.84 (0.61) |
| Medial frontal | 1.45 | 1.53 | 1.25 (0.28) | 1.39 | 1.50 | 2.05 | 1.48 (0.35) | 1.15 | 1.77 | 1.38 (0.54) |
| Lateral frontal | 1.58 | 2.21 | 1.39 (0.38) | 1.43 | 1.69 | 1.88 | 1.68 (0.50) | 1.15 | 2.28 | 1.46 (0.63) |
| Insula | 1.43 | 1.24 | 1.22 (0.15) | 1.12 | 1.14 | 1.35 | 1.22 (0.14) | 1.06 | 1.12 | 1.19 (0.21) |
| Mean cortical | 1.51 | 1.62 | 1.44 (0.30) | 1.53 | 1.58 | 1.82 | 1.72 (0.43) | 1.30 | 2.10 | 1.66 (0.51) |
| Frontal:Entorhinal | 1.19 | 0.99 | 0.89 (0.21) | 0.92 | 1.07 | 1.04 | 0.92 (0.21) | 0.78 | 1.16 | 0.78 (0.22) |
| Frontal:Parietal | 1.04 | 0.92 | 0.84 (0.14) | 0.79 | 0.89 | 1.18 | 0.83 (0.16) | 0.97 | 0.96 | 0.90 (0.20) |
*n=51 for education ADC.
†n=48 for education UCSF.
‡n=86 for education BioFINDER.
§n=50 for MMSE UCSF.
¶n=89 for MMSE BioFINDER.
**n=47 for APOE ε4 ADC.
††n=43 for APOE ε4 UCSF.
‡‡n=88 for APOE ε4 BioFINDER.
ADC, Amsterdam Dementia Cohort; bvAD, behavioural variant of Alzheimer’s disease; bvFTD, behavioural variant frontotemporal dementia; MMSE, mini mental state examination; SUVR, standardised uptake value ratios; UCSF, University of California San Francisco.