Table 3

Unadjusted and adjusted odds ratios for small vessel disease markers on CT and MRI in patients with intracerebral haemorrhage and prior anticoagulation therapy (vs no prior anticoagulation therapy)

			Unadjusted OR	P value	Adjusted* OR	P value
*Leukoaraiosis/white matter lesions*
CT	Anterior region		1.2 (1.0–1.4)	0.023	0.8 (0.6–1.1)	0.209
	Posterior region		1.2 (1.0–1.3)	0.038	0.8 (0.6–1.1)	0.234
MRI	Periventricular white matter		1.7 (1.2–2.4)	0.003	1.2 (0.6–2.3)	0.656
	Deep white matter		1.6 (1.2–2.1)	0.001	1.3 (0.8–2.2)	0.264
*Lacunes*
CT	Any lacunes		0.8 (0.5–1.2)	0.274	1.0 (0.5–2.2)	0.948
MRI	Any lacunes		1.5 (0.5–4.7)	0.451	0.6 (0.1–7.8)	0.666
*Atrophy*
CT	Cortical atrophy		2.0 (1.6–2.5)	<0.001	0.9 (0.6–1.4)	0.671
CT	Deep atrophy		1.6 (1.3–1.9)	<0.001	1.0 (0.7–1.5)	0.837
MRI	Global cortical atrophy		1.7 (1.2–2.3)	0.004	0.6 (0.3–1.4)	0.267
MRI	Medial temporal lobe		1.2 (0.9–1.7)	0.200	0.7 (0.4–1.2)	0.187
*Cerebral microbleeds, cortical superficial siderosis and perivascular spaces*
MRI	Perivascular spaces	Centrum semiovale	0.9 (0.7–1.2)	0.567	1.2 (0.7–2.0)	0.589
	Perivascular spaces	Basal ganglia	2.0 (1.2–3.2)	0.006	1.5 (0.6–3.6)	0.393
	Any cortical superficial siderosis		1.3 (0.4–4.2)	0.710	1.1 (0.1–1.7)	0.118
	Any cerebral microbleeds		1.6 (0.9–2.8)	0.098	1.8 (0.6–5.0)	0.279

*All CT analysis were adjusted for age, history of ischaemic stroke, history of ICH, atrial fibrillation, myocardial infarction, diabetes mellitus, hypertension, hypercholesterolaemia, current smoking and concomitant medication with antiplatelet agents, antihypertensive agents and statins.
*All MRI analysis were adjusted for age, hypertension, diabetes mellitus, atrial fibrillation, hypercholesterolaemia, current smoking and antihypertensive treatment.