Table 5

Regression model for analysing time to first secondary autoimmune disorder

Time to first development of secondary autoimmunityHR95% CIP value
Sex (male (57) vs female (113; ref.))1.5140.813 to 2.8200.191
Age (<34 years (84; ref.) vs ≥34 years (86))0.6710.356 to 1.2660.218
Annualised relapse rate at baseline0.9260.665-.12900.650
Baseline-EDSS1.0040.770 to 1.3190.974
Disease duration since onset (yrs)0.9970.931 to 1.0660.921
Last previous DMT (naïve=ref. (35)) basic (52)2.0430.770 to 5.4180.151
NTZ (50)1.8020.602 to 5.3930.293
FTY (33)5.8752.126 to 16.237 <0.001
  • Results from our Cox proportional hazard model using an enter method to integrate all the covariates in the final analysis. For analysis of age as a covariate, we split our group according to the median. Reference categories are indicated for categorical covariates. Numbers in brackets in the first column indicate sample numbers for the respective covariate.

  • Bold values indicate p-values below 0.05

  • DMT, disease-modifying treatment; EDSS, Expanded Disability Status Scale; FTY, fingolimod; NTZ, natalizumab.