Table 2

List of the clinically significant components with their corresponding involved brain regions

ComponentsRegions
1▴Superior frontal gyrus, ▴Middle frontal gyrus, ▴Superior frontal gyrus medial segment, ▴Anterior cingulate gyrus, ▴Opercular part of the inferior frontal gyrus
2▾Temporal pole, ▾Inferior temporal gyrus, ▾Middle temporal gyrus, ▾Middle cingulate gyrus, ▾Parahippocampal gyrus, ▾Precentral gyrus medial segment, ▾Posterior cingulate gyrus, ▾Entorhinal area, ▾Parietal lobule, ▾Fusiform gyrus
6▴Cerebellum, ▴Brain stem, ▴Pons, ▾Lingual gyrus, ▾Fusiform gyrus, ▾Temporal lobe ▾Parietal lobe
7▾Superior occipital gyrus, ▾Occipital lobe, ▾Lingual gyrus, ▾Calcalcarine cortex, ▾Precuneus, ▾Parietal lobe, ▾Temporal lobe, ▴Middle temporal gyrus, ▾Frontal lobe, ▴Precentral gyrus, ▾Supramarginal gyrus
8▾Brain stem, ▾Pons, ▾Ventral DC, ▾Thalamus, ▾Insula, ▾Accumbens, ▾Caudate, ▾Putamen, ▾Pallidum, ▾Frontal lobe ▴Temporal lobe
11▴Occipital pole, ▴Calcarine cortex, ▴Cuneus, ▾Middle temporal gyrus, ▾Inferior temporal gyrus, ▴Inferior occipital gyrus, ▾Angular gyrus, ▾Superior parietal lobule, ▾Supramarginal gyrus
13▾Lateral orbital gyrus, ▾Middle frontal gyrus, ▾Superior frontal gyrus, ▾Superior frontal gyrus medial segment, ▾Anterior orbital gyrus, ▾Medial frontal cortex, ▾Gyrus rectus, ▾Frontal pole, ▾Medial orbital gyrus, ▾Anterior cingulate gyrus, ▾Brain stem, ▾Lingual gyrus, ▾Temporal pole
15▴Thalamus, ▴Caudate, ▾Anterior insula, ▾Posterior insula, ▾Planum polare, ▴Putamen, ▾Frontal operculum, ▾Planum temporale, ▾Claustrum, ▾Triangular part of the inferior frontal gyrus, ▾Opercular part of the inferior frontal gyrus, ▴Precentral gyrus, ▾Central operculum, ▾Parietal operculum, ▾Frontal lobe ▾Temporal pole
17▴Hippocampus, ▴Pons, ▴Middle temporal gyrus, ▴Superior temporal gyrus, ▴Postcentral gyrus, ▴Triangular part of the inferior frontal gyrus, ▴Temporal pole, ▴Posterior orbital gyrus, ▴Medial orbital gyrus, ▴Anterior insula, Claustrum, ▴Basal forebrain, ▴Putamen, ▴Subcallosal area, ▴Medial orbital gyrus, ▴Gyrus rectus, ▴Medial frontal cortex, ▴Lateral orbital gyrus, ▴Orbital part of the inferior frontal gyrus, ▴Medial frontal cortex, ▴Anterior cingulate gyrus, ▴Anterior orbital gyrus, ▴Posterior cingulate gyrus, ▴Postcentral gyrus, ▴Frontal operculum, ▴Inferior temporal gyrus
18▾Middle occipital gyrus, ▾Postcentral gyrus, ▾Precentral gyrus, ▾Opercular part of the inferior frontal gyrus, ▾Fusiform gyrus, ▾Parahippocampal gyrus, ▾Frontal, ▾Occipital lobe ▾Parietal lobe, ▾Inferior temporal gyrus, ▾Middle temporal gyrus, ▾Superior temporal gyrus, ▾Supramarginal gyrus, ▾Middle temporal gyrus
20▴Superior occipital gyrus, ▴Superior parietal lobule, ▴Precuneus, ▴Posterior cingulate gyrus, ▴Superior frontal gyrus, ▴Middle frontal gyrus, ▴Angular gyrus, ▴Occipital lobule

  • We overlaid a whole brain parcellation mask with the identified ICA components in order to retrieve and label brain regions involved in each network. We correlated the loading of ICA components with the baseline volume of the areas involved in each network to identify which brain area in each network was atrophic (negative correlation between network loading and baseline volume) and which represented relative brain preservation (negative correlation between those volumes and ICA loadings).

  • ▴Relative preserved brain region.

  • ▾Atrophic brain region.

  • ICA, independent component analysis.