Table 2

Cox proportional hazards modelling for individual variables controlling for age at first study visit and sex

All dataExcluding ALS within 5 years
nCasesHR (95% CI)P valueAdjusted p valuenCasesHR (95% CI)P valueAdjusted p value
Total cholesterol469 5003261.00 (0.90 to 1.12)0.9600.960469 3541801.07 (0.93 to 1.24)0.3610.512
Total cholesterol:HDL ratio429 710294 1.17 (1.05 to 1.31) 0.006 0.031 429 578162 1.19 (1.03 to 1.39) 0.022 0.123
LDL cholesterol468 6183251.01 (0.91 to 1.12)0.8540.960468 4721791.11 (0.96 to 1.28)0.1540.356
HDL cholesterol429 789294 0.84 (0.73 to 0.96) 0.010 0.035 429 657162 0.81 (0.67 to 0.97) 0.022 0.123
Triglycerides469 1263261.08 (0.97 to 1.20)0.1480.325468 9801801.04 (0.90 to 1.20)0.6170.754
Apolipoprotein A1427 427291 0.83 (0.72 to 0.94) 0.005 0.031 427 297161 0.83 (0.70 to 0.99) 0.043 0.157
Apolipoprotein B467 1213241.01 (0.90 to 1.12)0.9160.960466 9761791.11 (0.96 to 1.28)0.1620.356
HbA1c466 4123230.98 (0.88 to 1.10)0.7700.960466 2671780.93 (0.78 to 1.10)0.3730.512
Excess MET402 3002750.93 (0.82 to 1.05)0.2590.475402 1791540.99 (0.84 to 1.16)0.8820.882
BMI499 3143361.04 (0.82 to 1.17)0.4440.698499 1661881.08 (0.93 to 1.25)0.3020.512
Creatinine469 2683260.86 (0.74 to 1.02)0.0760.210469 1221800.96 (0.79 to 1.17)0.6960.765
  • Hazard ratios indicated for a 1 SD increase in variable level.

  • ALS, amyotrophic lateral sclerosis; BMI, body mass index; HbA1c, glycated haemoglobin A1c; HDL, high density lipoprotein; HR, hazard ratio; LDL, low density lipoprotein; MET, metabolic equivalent task.