Table 3

Combined Cox proportional hazards modelling, controlling for age at first study visit and sex

All participantsExcluding ALS within 5 years
Model 1Model 2Model 3Model 4
HR (95% CI)P valueFDR p valueHR (95% CI)P valueFDR p valueHR (95% CI)P valueFDR p valueHR (95% CI)P valueFDR p value
LDL cholesterol1.12 (0.95 to 1.32)0.1920.356 1.35 (1.09 to 1.68) 0.007 0.021
HDL cholesterol 0.78 (0.64 to 0.96) 0.017 0.054 0.66 (0.49 to 0.88) 0.005 0.020
Apolipoprotein B1.06 (0.90 to 1.24)0.5070.638 1.23 (1.00 to 1.52) 0.050 0.129
Apolipoprotein A1 0.82 (0.68 to 0.97) 0.024 0.088 0.77 (0.61 to 0.98) 0.034 0.110
Triglycerides1.01 (0.87 to 1.19)0.8650.8651.04 (0.89 to 1.21)0.6170.6380.86 (0.68 to 1.08)0.1950.3290.94 (0.75 to 1.17)0.5710.675
HbA1c0.97 (0.83 to 1.12)0.6490.7670.96 (0.82 to 1.12)0.6210.6380.87 (0.69 to 1.10)0.2530.3650.86 (0.68 to 1.09)0.2190.356
Excess MET1.00 (0.99 to 1.00)0.2530.4111.00 (0.99 to 1.00)0.280.6161.00 (0.99 to 1.00)0.7710.8351.00 (0.99 to 1.00)0.7490.811
BMI1.01 (0.97 to 1.04)0.7320.7921.01 (0.97 to 1.04)0.6350.6381.03 (0.99 to 1.08)0.1870.3291.03 (0.99 to 1.08)0.1550.337
Creatinine1.00 (0.99 to 1.01)0.4080.5891.00 (0.99 to 1.01)0.4180.6381.00 (0.99 to 1.01)0.8490.8491.00 (0.99 to 1.01)0.9170.917
Smoking pack years1.00 (0.99 to 1.01)0.6290.7671.00 (0.99 to 1.01)0.6380.6381.01 (1.00 to 1.02)0.2020.3291.01 (1.00 to 1.02)0.2110.356
Cardiovascular disease 1.66 (1.10 to 2.49) 0.015 0.054 1.69 (1.12 to 2.54) 0.012 0.066 1.96 (1.16 to 3.30) 0.012 0.030 1.95 (1.16 to 3.29) 0.012 0.052
Cerebrovascular disease 3.25 (1.96 to 5.38) <0.001 <0.001 3.29 (1.99 to 5.45) <0.001 <0.001 3.94 (2.11 to 7.39) <0.001 <0.001 3.92 (2.09 to 7.34) <0.001 <0.001
Statin use0.68 (0.43 to 1.08)0.1040.2260.64 (0.41 to 1.00)0.0520.1430.77 (0.42 to 1.42)0.4040.4770.71 (0.39 to 1.29)0.2610.361
  • Four separate models were constructed for HDL and LDL cholesterol, and apoA1 and ApoA2, including and excluding participants going on to develop ALS within 5 years of sampling. Hazard ratios indicated for a 1 SD increase in variable level.

  • ALS, amyotrophic lateral sclerosis; BMI, body mass index; FDR, false discovery rate-adjusted p value; HbA1c, glycated haemoglobin A1c; HDL, high density lipoprotein; LDL, low density lipoprotein; MET, metabolic equivalent task.