Clinical outcomes 12 months after globus pallidus deep brain stimulation in patients with Parkinson’s disease (PD) (A). Programming parameters and distance from electrode contacts to globus pallidus motor nucleus (B)
| Patients with PD with SID (n=8) | Patients with PD without SID (n=15) | P value | |
| (A) | |||
| UPDRS III (medication off, stimulation on) | 33.50±12.87 | 32.13±7.91 | 0.925 |
| UPDRS III (medication off, stimulation off) | 37.68±14.89 | 41.46±8.39 | 0.441 |
| UPDRS III (medication on, stimulation on) | 20.68±14.09 | 15.23±8.88 | 0.266 |
| UPDRS III (medication on, stimulation off) | 26.00±15.56 | 22.13±12.87 | 0.728 |
| UPDRS IV (medication off, stimulation on) | 6.37±3.62 | 6.80±2.75 | 0.681 |
| Stimulation effect in medication off state | 4.18±3.18 | 9.33±4.77 | 0.013 |
| Stimulation effect in medication on state | 5.31±10.81 | 6.90±6.00 | 0.115 |
| LEDD (mg) | 1373.25±463.10 | 1272.86±322.19 | 0.548 |
| (B) | |||
| At initial programming | |||
| Voltage (V) | 2.18±0.39 | 2.77±0.47 | 0.001 |
| Parameter configuration | All monopolar | All monopolar | |
| At 12 months programming | |||
| Voltage (V) | 2.58±0.90 | 3.07±0.67 | 0.116 |
| Parameter configuration | Bipolar 3, monopolar 6, interleaving 1 | Bipolar 2, monopolar 28 | |
| Ventral contact to GPi motor nucleus (mm) | 1.87±1.31 | 1.48±1.11 | 0.287 |
| Active contact to GPi motor nucleus (mm) | 2.50±1.29 | 1.94±1.54 | 0.287 |
Data are represented as mean±SD.
Results in bold letters indicate significant difference between groups (p<0.05).
GPi, globus pallidus interna; LEDD, Levodopa equivalent daily dose; SID, stimulus-induced dyskinaesia; UPDRS, Unified Parkinson’s Disease Rating Scale.;