Incidence rates (IR) and incidence rate ratios (IRR) of clinical events
| Measure | All Patients | Control | Case | |
|---|---|---|---|---|
| IR per 100 person years (95% CI ) | IRR (95% CI ) | |||
| Depression | 0.6 (0.5–0.6) | 0.3 (0.3–0.4) | 1.9 (1.7–2.3) | 6.0 (5.7–6.4) |
| Anxiety disorders | 0.5 (0.4–0.5) | 0.3 (0.2–0.3) | 1.3 (1.1–1.6) | 4.4 (4.2–4.7) |
| Obsessive Compulsive Disorder | 0.02 (0.01–0.04) | 0.01 (0.004–0.03) | 0.07 (0.03–0.1) | 5.7 (5.4–6.0) |
| Dementia | 0.4 (0.4–0.5) | 0.3 (0.3–0.4) | 1.0 (0.8–1.2) | 2.8 (2.7–3.0) |
| Hydrocephalus | 0.03 (0.01–0.04) | 0.02 (0.01–0.04) | 0.04 (0.01–0.1) | 1.6 (1.5–1.7) |
| Epilepsy | 0.1 (0.1–0.2) | 0.08 (0.06–0.1) | 0.3 (0.2–0.5) | 4.2 (3.9–4.4) |
| Communication and speech problems | 0.2 (0.2–0.3) | 0.1 (0.09–0.1) | 0.7 (0.6–0.9) | 6.4 (6.1–6.8) |
| Hypertension | 4.0 (3.8–4.2) | 4.3 (4.1–4.6) | 2.4 (2.0–2.7) | 0.5 (0.5–0.6) |
| Chronic renal impairment | 0.3 (0.3–0.3) | 0.3 (0.3–0.4) | 0.2 (0.1–0.3) | 0.7 (0.6–0.7) |
| Asthma | 0.3 (0.2–0.3) | 0.3 (0.2–0.3) | 0.2 (0.2–0.4) | 0.9 (0.8–0.9) |
| Liver failure | 0.09 (0.06–0.1) | 0.09 (0.07–0.1) | 0.05 (0.02–0.1) | 0.5 (0.5–0.5) |
| Gastrointestinal events | 2.9 (2.7–3.0) | 2.8 (2.6–2.9) | 3.5 (3.1–3.9) | 1.3 (1.2–1.3) |
| Thyroid disorders (hyper or hypothyroid) | 0.4 (0.3–0.4) | 0.4 (0.4–0.5) | 0.3 (0.2–0.5) | 0.8 (0.8–0.8) |
| Bone marrow disorders | 0.6 (0.5–0.6) | 0.5 (0.5–0.6) | 0.7 (0.6–0.9) | 1.4 (1.3–1.5) |
| Cancer | 1.3 (1.2–1.4) | 1.4 (1.3–1.5) | 0.9 (0.8–1.1) | 0.7 (0.6–0.7) |
| Neuritis | 0.05 (0.03–0.07) | 0.05 (0.03–0.07) | 0.05 (0.02–0.1) | 1.0 (1.0–1.1) |
| Myelitis | 0.005 (0.001–0.01) | 0.006 (0.001–0.02) | N/A | N/A |
| Radiculitis | 0.007 (0.002–0.02) | 0.006 (0.001–0.02) | 0.01 (0.0002–0.05) | 1.6 (1.5–1.7) |
| Meningitis | 0.03 (0.01–0.04) | 0.02 (0.01–0.04) | 0.05 (0.02–0.1) | 2.2 (2.1–2.4) |
| Acute psychiatric episode | 0.06 (0.05–0.09) | 0.02 (0.009–0.04) | 0.3 (0.2–0.4) | 14.4 (13.6–15.2) |
| Cerebrovascular illness | 0.5 (0.5–0.6) | 0.5 (0.4–0.5) | 0.7 (0.6–0.9) | 1.5 (1.5–1.6) |
| Cardiovascular disease | 0.7 (0.6–0.8) | 0.7 (0.6–0.8) | 0.7 (0.5–0.9) | 1.0 (1.0–1.1) |
| Pneumonia | 0.9 (0.9–1.0) | 0.7 (0.6–0.8) | 2.3 (2.0–2.6) | 3.4 (3.2–3.6) |
| Acute respiratory symptoms | 2.1 (2.0–2.2) | 2.0 (1.9–2.2) | 2.4 (2.1–2.8) | 1.2 (1.1–1.3) |
| Fractures | 1.9 (1.7–2.0) | 1.6 (1.5–1.7) | 3.2 (2.8–3.6) | 1.9 (1.8–2.1) |
| Subdural haematoma | 0.06 (0.04–0.09) | 0.03 (0.02–0.05) | 0.2 (0.1–0.3) | 7.5 (7.1–7.9) |
| Bleeding events | 1.6 (1.5–1.7) | 1.5 (1.4–1.6) | 2.3 (2.0–2.7) | 1.6 (1.5–1.7) |
| Thrombocytopenia | 0.05 (0.03–0.07) | 0.05 (0.03–0.07) | 0.04 (0.01–0.1) | 0.8 (0.8–0.9) |
| Constipation | 4.4 (4.2–4.6) | 3.7 (3.6–3.9) | 8.4 (7.7–9.1) | 2.2 (2.1–2.4) |
CI, confidence interval; HD, Huntington’s disease; IR, incidence rate; IRR, incidence rate ratio.
IR = Number of patients that had a first event on or after index, divided by the total at-risk person time from index until the event or end of follow-up (earliest of end of data, death or migration). Size of the denominator population is different for each analytical set since only patients without an event prior to index were included.
IRR = IR in HD cohort/IR in control cohort (scores >1 reflect higher relative risk of an event in HD compared to controls).