Table 2

Cox regression models showing associations between anticoagulation status before the stroke and recurrent ischaemic events and symptomatic intracranial haemorrhage

Recurrent ischaemic eventSymptomatic intracranial haemorrhage
Unadjusted1.31 (0.89–1.94),
p=0.171		1.15 (0.50–2.66),
p=0.744
Model 11.29 (0.87–1.90),
p=0.208		1.16 (0.50–2.68),
p=0.731
Model 21.41 (0.94–2.11),
p=0.102		1.14 (0.50–2.65),
p=0.748
Model 31.50 (0.99–2.28),
p=0.058		1.08 (0.46–2.51),
p=0.862

  • Recurrent ischaemic event: model 1 adjusted for CHA2DS2Vasc and model 2 adjusted for CHA2DS2Vasc, ipsilateral large artery disease with 50% or more luminal narrowing and ischaemic lesion <10 mL, model 3 adjusted for model 2 plus anticoagulation initiated or continued (vs not.)

  • sICH: model 1 adjusted for age, sex and ischaemic lesion <10 mL; model 2 adjusted for model 1 and bridging with LMWH/heparin; model 3 adjusted for model 2 plus anticoagulation initiated.

  • LMWH, low-molecular-weight heparin; sICH, symptomatic intracranial haemorrhage.