Table 2

Comparisons of blood phosphorylated tau (P-tau) among diagnostic groups stratified by Aβ status

ResultCohortTechnology typeP-tau isoformRef
↑ Blood P-tau in Aβ+ AD or neuropathologically confirmed AD vs non-AD neurodegenerative diseasesTRIAD and BioFINDER-2SimoaP-tau181 48
SimoaP-tau181 49
Neuropathology cohortSimoaP-tau181 50
SimoaP-tau181 51
BioFINDER (cohort 1) and a neuropathology cohortMSDP-tau181 52
UCSF Memory, Aging Center and ARTFL (cohort 1), and a neuropathology cohortMSDP-tau181 53
BioFINDER-2 and a neuropathology cohortMSDP-tau217 45
TRIAD and a neuropathology cohortSimoaP-tau231 46
↑ Blood P-tau in Aβ+ AD vs Aβ− ADSimoaP-tau181 51
SimoaP-tau181 55
↑ Blood P-tau in Aβ+ AD vs Aβ+ MCITRIAD and BioFINDER-2SimoaP-tau181 48
BioFINDER-2MSDP-tau217 45
TRIADSimoaP-tau231 46
↑ Blood P-tau in Aβ+ AD vs Aβ− MCITRIAD and BioFINDER-2SimoaP-tau181 48
SimoaP-tau181 55
BioFINDER-2MSDP-tau217 45
TRIADSimoaP-tau231 46
↑ Blood P-tau in Aβ+ AD vs Aβ+ CU and Aβ− CUTRIAD and BioFINDER-2SimoaP-tau181 48
SimoaP-tau181 55
MSDP-tau181 54
BioFINDER (cohort 1)MSDP-tau181 52
BioFINDER-2MSDP-tau217 45
TRIADSimoaP-tau231 46
↑ Blood P-tau in Aβ+ MCI vs Aβ− MCIBioFINDER-2SimoaP-tau181 48
SimoaP-tau181 51
SimoaP-tau181 55
BioFINDER (cohort 2)MSDP-tau181 52
BioFINDER-2MSDP-tau217 45
TRIADSimoaP-tau231 46
↑ Blood P-tau in Aβ+ MCI vs Aβ+ CUSimoaP-tau181 55
BioFINDER (cohort 1 and 2)MSDP-tau181 52
↑ Blood P-tau in Aβ+ MCI vs Aβ− CUTRIAD and BioFINDER-2SimoaP-tau181 48
SimoaP-tau181 51
SimoaP-tau181 55
BioFINDER (cohort 1 and 2)MSDP-tau181 52
MSDP-tau181 54
Validation cohortIP-MSP-tau181 47
BioFINDER-2MSDP-tau217 45
Validation cohortIP-MSP-tau217 47
TRIADSimoaP-tau231 46
↑ Blood P-tau in Aβ+ CU vs Aβ− CUTRIAD and BioFINDER-2SimoaP-tau181 48
SimoaP-tau181 55
BioFINDER (cohort 1 and 2)MSDP-tau181 52
BioFINDER-2MSDP-tau217 45
Validation cohortIP-MSP-tau217 47
TRIADSimoaP-tau231 46
↑ Blood P-tau in Aβ+ CU vs Aβ− MCIBioFINDER-2SimoaP-tau181 48
BioFINDER (cohort 2)MSDP-tau181 52
BioFINDER-2MSDP-tau217 45
TRIADSimoaP-tau231 46
  • Aβ, amyloid-β; AD, Alzheimer’s disease; CU, Cognitively unimpaired; IP-MS, immunoprecipitation-mass spectrometry; MCI, mild cognitive impairment; MSD, Meso Scale Discovery; Simoa, single molecule array; UCSF, University of California at San Francisco.