Status epilepticus trials for emergency presentations reporting rate of misdiagnosis
Study | Centres (n), country | Age group | Initial diagnosis made by | Sample size | Rate of misdiagnosis (%) | Proportion of misdiagnoses specified as pPNES |
Leppik et al 8 | 3, USA | Adults | Physicians, hospital-based | 78 | 13.5 | 1/11 |
Alldredge et al 9 | 10, USA | Adults | Paramedics | 205 | 5 | 10/10 |
Silbergleit et al 10* | 79, USA | Both (children ≥40 kg) | Paramedics | 893 | 7.1 | 63/63 |
Chamberlain et al 11 | 11, USA | Paediatric (3 months–18 years) | Physicians, hospital-based | 310 | 10 | ns |
Mundlamuri et al 12 | 1, India | Both (15–65 years) | Physicians, hospital-based | 150 | 0.05 | 1/1 |
Sánchez Fernández et al 13 | 9, USA | Paediatric (1 month–21 years) | Paramedics | 81 | 0 | – |
Welch et al 14* | 79, USA | Paediatric (weight ≥13 kg) | Paramedics | 120 | 8.3 | 8/10 |
Navarro et al 15 | 39, France | Adults | Physicians, prehospital | 136 | 4.4 | 6/6 |
Kapur et al 16† | 57, USA | Both (≥2 years) | Physicians, hospital-based | 384 | 9.6 | 37/37 |
Chamberlain et al 17† | 58, USA | Both (≥2 years) | Physicians, hospital-based | 462 | ns‡ | ns‡ |
See online supplemental material for search strategy and flow diagram of literature review.
*Publication part of RAMPART.
†Publication part of ESETT.
‡See the Results section for the results of individual patient data analysis.
ESETT, Established Status Epilepticus Treatment Trial; ns, not specified; pPNES, prolonged psychogenic non-epileptic seizures; RAMPART, Rapid Anticonvulsant Medication Prior to Arrival Trial.