Table 1

Characteristics of the study cohort

VariableEntire cohortA−TN–A+TN–A+TN+A−TN+P value
Numbers (N)865260173300132
Age at bl, mean (SD) in years73 (7)71 (7)73 (7)74 (7)74 (8)<0.001*
Female no (%)399 (46)129 (50)62 (36)143 (48)65 (49)0.02*
Education, mean (SD) years16.3 (2.6)16.4 (2.6)16.5 (2.7)16 (2.7)16.3 (2.4)0.12*
APOE genotype positive, no (%)478 (55)211 (81)88 (51)88 (30)91 (69)<0.001†
Plasma p-tau181 (pg/mL), mean (SD)19 (18)13 (9)17 (10)24 (11)20 (39)<0.001*
Plasma NfL (pg/mL), mean (SD)39 (21)33 (19)38 (17)45 (19)40 (30)<0.001*
CSF Aβ42 (pg/mL), mean (SD)1106 (607)1567 (396)665 (197)662 (166)1784 (641)<0.001*
CSF t-tau (pg/ml), mean (SD)282 (131)191 (40)181 (44)389 (124)349 (106)<0.001*
CSF p-tau181 (pg/mL), mean (SD)27 (14)17 (4)17 (5)39 (13)32 (11)<0.001*
MMSE, score, mean (SD)27 (3)29 (2)28 (2)26 (3)28 (2)<0.001*
ADNI-mem, score, mean (SD)0.4 (0.9)0.9 (0.7)0.4 (0.8)−0.3 (0.9)0.7 (0.8)<0.001*
CDR score, mean (SD)0.39 (0.32)0.28 (0.26)0.37 (0.29)0.55 (0.35)0.27 (0.29)<0.001*
  • *ANOVA.

  • †χ² test on independence.

  • Aβ, amyloid β; A+/−, amyloid-β positive/negative; ADNI, Alzheimer’s Disease Neuroimaging Initiative; ANOVA, analysis of variance; ATN, Aβ deposition, tau pathology and neurodegeneration; bl, baseline; CDR, clinical dementia rating; CSF, cerebrospinal fluid; mem, memory; MMSE, Mini-Mental State Examination; NfL, neurofilament light protein; p-tau181, plasma phosphorylated tau 181; sob, sum of boxes; TN+/−, tau/neurodegeneration positive/negative.