Table 3

Optimal cut-off values separating patients from controls

	pNfL value	AUC	Youden	Se	Sp
C9orf72 patients versus controls
Overall	19.00	0.93	0.71	0.83	0.88
<50 years	9.74	0.87	0.66	0.83	0.82
50.0–59.9 years	16.03	1	1	1	1
60.0–69.9 years	20.85	0.92	0.65	0.81	0.84
≥70 years	26.47	0.90	0.76	0.88	0.88
GRN patients versus controls
Overall	27.48	0.97	0.91	0.94	0.97
<50 years	15.70	0.77	0.73	0.75	0.98
50.0–59.9 years	17.77	1	1	1	1
60.0–69.9 years	35.69	0.97	0.96	0.96	1
≥70 years	27.71	0.98	0.88	1	0.88

Values are indicated in pg/mL.
AUC, area under the curve; pNfL, plasma neurofilament light chain; Se, sensitivity; Sp, specificity.