Demographics | Cohort | |||||

SCANS | RUN DMC | HARMONISATION | PRESERVE | ASPS-Fam | CADASIL | |

Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |

Age (years) | 70.01 (9.75) | 65.62 (8.81) | 72.23 (8.47) | 68.07 (9.11) | 65.43 (10.67) | 47.90 (9.77) |

Sex, male (%) | 78 (0.65) | 284 (0.57) | 57 (0.45) | 43 (0.39) | 139 (0.40) | 26 (0.45) |

Included in cross-sectional analysis | Yes | Yes | Yes | Yes | Yes | Yes |

Sample size with complete DTI and MRI baseline | 115 | 499 | 127 | 101 | 243 | 54 |

Included in longitudinal analysis | Yes | Yes | Yes | No | No | No |

Dementia cases with baseline MRI and DTI measures | 20 | 65 | 23 | – | – | – |

Sample size in longitudinal dementia analysis with complete repeated MRI and DTI | 99 | 257 | 120 | – | – | – |

Dementia cases with repeated MRI and DTI measures | 18 | 12 | 21 | – | – | – |

Baseline complete DTI, MRI parameter | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) |

MD median (mm ^{2}/s) | 8.00e-04 (4.08–05) | 8.30e-04 (3.71e-05) | 8.82e-04 (6.08e-05) | 7.87e-04 (4.39e-05) | 7.69e-04 (3.03e-05) | 8.89e-04 (1.30e-04) |

Brain volume (mL) | 1295.94 (92.37) | 1060.82 (80.15) | 1088.87 (128.83) | 1349.19 (104.26) | 1460.02 (144.38) | 1171.88 (113.51) |

Baseline MRI count parameter | Median (range) | Median (range) | Median (range) | Median (range) | Median (range) | Median (range) |

WMH | 3.11 (0.29–23.23)* | 0.34 (0.01–12.93)* | 2.70 (0–82.89)† | 2.90 (0.29–9.32)* | 3.90 (0.07–137.16)† | 95.24 (0.66–307.18)† |

Lacune | 2 (0–27) | 0 (0–11) | 0 (0–8) | 2 (0–23) | 0 (0–7) | 2.5 (0–32) |

CMB | 0 (0–144) | 0 (0–54) | 0 (0–95) | 0 (0–44) | 0 (0–9) | 0 (0–16) |

Baseline cognition with complete imaging | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) |

Global cognition | −0.654 (0.833) | −0.015 (0.728) | −0.582 (0.892) | −0.789 (0.957) | 0.033 (1.028) | – |

TMT-B | – | – | – | – | – | −2.88 (4.08) |

*% ratio of WMH volume to the total cerebral volume.

†WMH volume in mL.

CMB, cerebral microbleeds; DTI, diffusion tensor imaging; MD, mean diffusivity; TMT-B, Trail-making Test version B; WMH, white matter hyperintensity.