Table 2

Demographic, imaging and cognition measures in each cohort studies

DemographicsCohort
SCANSRUN DMCHARMONISATIONPRESERVEASPS-FamCADASIL
Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)
Age (years)70.01 (9.75)65.62 (8.81)72.23 (8.47)68.07 (9.11)65.43 (10.67)47.90 (9.77)
Sex, male (%)78 (0.65)284 (0.57)57 (0.45)43 (0.39)139 (0.40)26 (0.45)
Included in cross-sectional analysisYesYesYesYesYesYes
Sample size with complete DTI and MRI baseline11549912710124354
Included in longitudinal analysisYesYesYesNoNoNo
Dementia cases with baseline MRI and DTI measures206523
Sample size in longitudinal dementia analysis with complete repeated MRI and DTI99257120
Dementia cases with repeated MRI and DTI measures181221
Baseline complete DTI, MRI parameterMean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)
MD median
(mm2/s)
8.00e-04
(4.08–05)
8.30e-04
(3.71e-05)
8.82e-04
(6.08e-05)
7.87e-04
(4.39e-05)
7.69e-04
(3.03e-05)
8.89e-04
(1.30e-04)
Brain volume
(mL)
1295.94
(92.37)
1060.82
(80.15)
1088.87
(128.83)
1349.19
(104.26)
1460.02
(144.38)
1171.88
(113.51)
Baseline
MRI count parameter
Median (range)Median (range)Median (range)Median (range)Median (range)Median (range)
WMH3.11
(0.29–23.23)*
0.34
(0.01–12.93)*
2.70
(0–82.89)†
2.90
(0.29–9.32)*
3.90
(0.07–137.16)†
95.24
(0.66–307.18)†
Lacune2 (0–27)0 (0–11)0 (0–8)2 (0–23)0 (0–7)2.5 (0–32)
CMB0 (0–144)0 (0–54)0 (0–95)0 (0–44)0 (0–9)0 (0–16)
Baseline cognition with complete imagingMean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)
Global cognition−0.654 (0.833)−0.015 (0.728)−0.582 (0.892)−0.789 (0.957)0.033 (1.028)
TMT-B−2.88 (4.08)
  • *% ratio of WMH volume to the total cerebral volume.

  • †WMH volume in mL.

  • CMB, cerebral microbleeds; DTI, diffusion tensor imaging; MD, mean diffusivity; TMT-B, Trail-making Test version B; WMH, white matter hyperintensity.