Table 1

Overview about the cohort studies included in the OPTIMAL project

CohortNo of patientsCountryInclusion criteriaDementia diagnosisVascular dementiaAlzheimer’s disease
SCANS
(St George's cognition and neuroimaging in stroke)
121UKSymptomatic SVD defined as a clinical lacunar stroke syndrome with MRI evidence of an anatomically corresponding lacunar infarct, and with confluent regions of WMH graded ≥2 on the modified Fazekas scale.40 Diagnostic and Statistical Manual of Mental Disorders V
PRESERVE
(How intensively should we treat blood PRESsure in established cERebral small VEssel disease?’)
111UKSymptomatic SVD defined as a clinical lacunar stroke syndrome with MRI evidence of an anatomically corresponding lacunar infarct, and with confluent regions of WMH graded ≥2 on the modified Fazekas scale.40
RUN DMC
(Radboud University Nijmegen Diffusion Imaging and Magnetic Resonance Imaging Cohort)
503The NetherlandsSVD defined as the presence of lacunes and or WMH on neuroimaging.Diagnostic and Statistical Manual of Mental Disorders IVNational Institute of Neurological Disorders and Stroke-
Association Internationale pour la Recherché et l’Enseignement en Neurosciences criteria.41
National Institute on Ageing and Alzheimer’s Association criteria.42
HARMONISATION127SingaporePatients with mild cognitive impairment impaired in at least one cognitive domain of a formal neuropsychological test battery, with or without a history of stroke.Diagnostic and Statistical Manual of Mental Disorders IVNational Institute of Neurological Disorders and Stroke-
Association Internationale pour la Recherché et l’Enseignement en Neurosciences criteria.41
National Institute on Ageing and Alzheimer’s Association criteria.42
ASPS-Fam
(Austrian stroke prevention family study)
382AustriaBeing free of dementia and stroke as well as demonstrating normal neurological function.
CADASIL
(Munich CADASIL cohort)
58GermanyDiagnosis of CADASIL confirmed by genetic testing or skin biopsy.
  • The table shows the number of patients enrolled, the respective inclusion criteria and the type of dementia diagnosis given in each study.

  • OPTIMAL, OPtimising mulTImodal MRI markers for use as surrogate markers in trials of Vascular Cognitive Impairment due to cerebrAl small vesseL disease; SVD, small vessel disease; WMH, white matter hyperintensity.