Characteristics of included patients by randomly allocated treatment group
| Characteristics | Randomly allocated treatment group | Standardised difference* | |
| Active/intensive (N=3121) | Placebo/guideline (N=3100) | ||
| Age, years | 64.0 (13.0) | 64.3 (12.9) | 0.028 |
| Sex (female) | 1146/3121 (36.7) | 1120/3100 (36.1) | 0.012 |
| Geographical region† | |||
| Americas | 520/3121 (16.7) | 511/3100 (16.5) | 0.026 |
| Asia | 1734/3121 (55.6) | 1760/3100 (56.8) | |
| Europe/Australia | 867/3121 (27.8) | 829/3100 (26.7) | |
| SBP at randomisation, mm Hg | 177.3 (20.1) | 177.4 (20.5) | 0.007 |
| DBP at randomisation, mm Hg | 99.9 (15.5) | 100.1 (15.8) | 0.014 |
| NIHSS score | 11.0 (7.0 to 16.2) | 11.1 (7.0 to 16.0) | 0.028 |
| GCS score | 14.0 (12.0 to 15.0) | 14.0 (13.0 to 15.0) | 0.005 |
| History of hypertension | 2219/3023 (73.4) | 2179/2998 (72.7) | 0.016 |
| History of diabetes mellitus | 405/2987 (13.6) | 364/2975 (12.2) | 0.039 |
| History of stroke | 513/3014 (17.0) | 503/2994 (16.8) | 0.006 |
| History of ischaemic heart disease | 273/2815 (9.7) | 275/2827 (9.7) | 0.001 |
| Current use of antihypertensive drugs | 1194/2653 (45.0) | 1183/2652 (44.6) | 0.008 |
| Current antiplatelet therapy | 163/1734 (9.4) | 178/1741 (10.2) | 0.028 |
| Current anticoagulation | 64/1716 (3.7) | 43/1731 (2.5) | 0.072 |
| Haematoma volume, mL | 10.6 (5.1 to 20.5) | 10.7 (5.4 to 20.7) | 0.037 |
| Haematoma location | |||
| Lobar | 249/1942 (12.8) | 257/1921 (13.4) | 0.017 |
| Basal ganglia/deep | 1589/1942 (81.8) | 1547/1921 (80.5) | 0.033 |
| Infratentorial/posterior fossa | 104/1942 (5.4) | 117/1921 (6.1) | 0.032 |
| Intraventricular haemorrhage | 815/2729 (29.9) | 808/2691 (30.0) | 0.004 |
| Time from symptom onset to randomisation, hour | 3.8 (2.5 to 5.4) | 3.8 (2.6 to 5.2) | 0.018 |
| Process of care variables | |||
| DNAR | 133/2177 (6.1) | 109/2200 (5.0) | 0.051 |
| Intubation | 204/2324 (8.8) | 181/2338 (7.7) | 0.038 |
| Neurosurgery | 133/2322 (5.7) | 142/2338 (6.1) | 0.015 |
Data are numbers (%), mean (SD) or median (IQR).
*A standardised difference of 10% (or 0.1) is equivalent to a p=0.05.
†Geographical region denotes the country in which patients were treated.
DBP, diastolic blood pressure; DNAR, do not attempt resuscitation order; GCS, Glasgow Coma Scale; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure.