Table 3

Cross-sectional analysis between DTI measures and Global Cognition or TMT-B (CADASIL) independently of the clinical markers

SCANS*RUN DMC*HARMONISATION*PRESERVE*ASPS-Fam*CADASIL†
MD median−0.232 (0.068), p=0.001
Adj. R2=0.478, Norm. Cont R2 (95% CI)=0.170 (0.030 to 0.330)
−0.218 (0.040), p=8.76e-08
Adj. R2=0.454, Norm. Cont R2 (95% CI)=0.237 (0.167 to 0.317)
−0.344 (0.077), p=1.98e-05
Adj. R2=0.456, Norm. Cont R2 (95% CI)=0.192 (0.076 to 0.336)
−0.410 (0.087), p=9.19e-06
Adj. R2=0.373, Norm. Cont R2 (95% CI)=0.297 (0.105 to 0.464)
−0.149 (0.055), p=0.008,
Adj. R2=0.516, Norm. Cont R2 (95% CI)=0.173 (0.093 to 0.273)
−0.516 (0.177), p=0.0055
Adj. R2=0.235, Norm. Cont R2 (95% CI)=0.650 (0.235 to 0.812)
FA median0.267 (0.069), p=0.0002
Adj. R2=0.492, Norm. Cont R2 (95% CI)=0.200 (0.066 to 0.342)
0.098 (0.034), p=0.004
Adj. R2=0.431, Norm. Cont R2 (95% CI)=0.025 (0.002 to 0.072)
0.268 (0.072), p=0.0003
Adj. R2=0.433, Norm. Cont R2 (95% CI)=0.171 (0.057 to 0.324)
0.400 (0.082), p=4.08e-06
Adj. R2=0.383, Norm. Cont R2 (95% CI)=0.394 (0.156 to 0.562)
0.119 (0.051), p=0.020,
Adj. R2=0.512, Norm. Cont R2 (95% CI)=0.100 (0.037 to 0.203)
0.515 (0.162), p=0.0027
Adj. R2=0.257, Norm. Cont R2 (95% CI)=0.677 (0.299 to 0.789)
MDPH0.315 (0.067), p=7.17e-06
Adj. R2=0.520, Norm. Cont R2 (95% CI)=0.231 (0.091 to 0.389)
0.210 (0.043), p=1.25e-06
Adj. R2=0.448, Norm. Cont R2 (95% CI)=0.244 (0.175 to 0.314)
0.338 (0.077), p=2.36e-05
Adj. R2=0.455, Norm. Cont R2 (95% CI)=0.188 (0.082 to 0.337)
0.316 (0.090), p=0.001
Adj. R2=0.314, Norm. Cont R2 (95% CI)=0.195 (0.032 to 0.371)
0.009 (0.050), p=0.865
Adj. R2=0.500, Norm. Cont R2 (95% CI)=0.026 (0.008 to 0.075)
0.451 (0.179), p=0.015
Adj. R2=0.202, Norm. Cont R2 (95% CI)=0.609 (0.207 to 0.747)
FAPH−0.249 (0.069), p=0.001
Adj. R2=0.484, Norm. Cont R2 (95% CI)=0.122 (0.028 to 0.263)
−0.093 (0.034), p=0.006
Adj. R2=0.430, Norm. Cont R2 (95% CI)=0.012 (0.002 to 0.044)
−0.239 (0.076), p=0.002
Adj. R2=0.416, Norm. Cont R2 (95% CI)=0.156 (0.053 to 0.304)
−0.374 (0.083), p=1.72e-05
Adj. R2=0.364, Norm. Cont R2 (95% CI)=0.357 (0.126 to 0.545)
0.022 (0.050), p=0.664
Adj. R2=0.500, Norm. Cont R2 (95% CI)=0.020 (0.006 to 0.072)
−0.454 (0.154), p=0.005
Adj. R2=0.237,
Norm. Cont R2 (95% CI)=0.630 (0.209 to 0.797)
MD pkval−0.178 (0.069), p=0.011
Adj. R2=0.456, Norm. Cont R2 (95% CI)=0.110 (0.010 to 0.280)
−0.146 (0.040), p=2.69e-04
Adj. R2=0.437, Norm. Cont R2 (95% CI)=0.174 (0.112 to 0.249)
−0.099 (0.073), p=0.177
Adj. R2=0.377, Norm. Cont R2 (95% CI)=0.027 (0.003 to 0.152)
−0.365 (0.089), p=8.53e-05
Adj. R2=0.343, Norm. Cont R2 (95% CI)=0.254 (0.076 to 0.444)
−0.109 (0.054), p=0.044
Adj. R2=0.509, Norm. Cont R2 (95% CI)=0.130 (0.065 to 0.216)
−0.610 (0.173), p=0.001
Adj. R2=0.241, Norm. Cont R2 (95% CI)=0.757 (0.214 to 0.904)
FA pkval0.228 (0.069), p=0.001
Adj. R2=0.476, Norm. Cont R2 (95% CI)=0.053 (0.009 to 0.123)
0.006 (0.037), p=0.864
Adj. R2=0.421, Norm. Cont R2 (95% CI)=0.037 (0.017 to 0.078)
0.095 (0.077), p=0.216
Adj. R2=0.375, Norm. Cont R2 (95% CI)=0.021 (0.005 to 0.123)
0.257 (0.088), p=0.004
Adj. R2=0.288, Norm. Cont R2 (95% CI)=0.197 (0.016 to 0.427)
0.086 (0.048), p=0.072
Adj. R2=0.507, Norm. Cont R2 (95% CI)=0.057 (0.010 to 0.142)
0.159 (0.144), p=0.274
Adj. R2=0.0655, Norm. Cont R2 (95% CI)=0.305 (0.028 to 0.656)
  • Values show standardised regression coefficients: β (SE) for predictor variables in linear regression models of Global Cognition or TMT-B in CADASIL. P-value < 0.05 are marked in bold. Adjusted R2 refers to the overall explained variance adjusted for the number of predictors in the model. DTI’s normalised R2 contribution to the overall model together with the 95% CI is also shown.

  • *Linear regression analysis with Global cognition as outcome measure

  • †Linear regression analysis with TMT-B as outcome measure

  • DTI, diffusion tensor imaging; FA, fractional anisotropy; MD, mean diffusivity; PH, peak height; pkval, peak value of the histogram; TMT-B, Trail-making Test version B.