Table 2

Cognitive/Motor ratio cohort demographics

VariableAll patients (all prion aetiologies)Patients with sCJD
No. of patients (total paired records)No. with MRC (total paired records)Mean first assessment MRC±SD
(95% CI)
Mean first assessment Motor100*±SD
(95% CI)
Mean first assessment Cog100*±SD
(95% CI)
No. of patients (records)No. with MRC (records)Mean first assessment MRC±SD
(95% CI)
Mean first assessment Motor100*±SD
(95% CI)
Mean first assessment Cog100±SD
(95% CI)
At least one paired Motor and Cognitive Scale score570 (1286)545 (1169)7.4±6.9
(6.8 to 8.0)
30.3±29.4
(27.9 to 32.8)
27.0±31.8
(24.4 to 29.7)
435
(728)
427
(690)
6.1±6.1
(5.5 to 6.7)
24.6±26.0
(21.1 to 27.1)
22.0±29.5
(19.2 to 24.8)
Aetiology
 sCJD435 (76.3)435 (100.0)
 vCJD12 (2.1)
 Inherited104 (18.2)
 Iatrogenic19 (3.3)
 Gender M/F71/64201/234
Mean age (SD)45.7 (12.4)66.4 (9.1)
 Codon 129
 MM (%)252 (44.2)178 (40.9)
 MV (%)150 (26.3)103 (23.7)
 VV (%)97 (17.0)89 (20.5)
 Unknown (%)71 (12.5)65 (14.9)
  • *Motor and Cognitive Scale scores transformed to scores/100 according to the Rasch model.

  • MRC, Medical Research Council; sCJD, sporadic Creutzfeldt-Jakob disease; vCJD, variant CJD.