Sample sizes for small to moderate effect sizes on progression in mean FRS percentage score and mean CDR+NACC FTLD Sum of Boxes score, in mutation carriers with a global rating of 0.5
| Effect size on progression in mean score | |||||
| 30% | 25% | 20% | 15% | 10% | |
| FRS percentage score | |||||
| N (per arm) | 181 | 261 | 408 | 725 | 1630 |
| CDR+NACC FTLD Sum of Boxes score | |||||
| N (per arm) | 329 | 474 | 740 | 1315 | 2960 |
CDR+NACC FTLD=CDR Dementia Staging Instrument plus Behaviour and Language domains from the NACC FTLD module.
CDR, Clinical Dementia Rating; FRS, Frontotemporal dementia Rating Scale; FTLD, Frontotemporal Lobar Degeneration; NACC, National Alzheimer’s Disease Coordinating Center.