Table 4

Sample sizes for small to moderate effect sizes on progression in mean FRS percentage score and mean CDR+NACC FTLD Sum of Boxes score, in mutation carriers with a global rating of 0.5

Effect size on progression in mean score
FRS percentage score
 N (per arm)1812614087251630
CDR+NACC FTLD Sum of Boxes score
 N (per arm)32947474013152960
  • CDR+NACC FTLD=CDR Dementia Staging Instrument plus Behaviour and Language domains from the NACC FTLD module.

  • CDR, Clinical Dementia Rating; FRS, Frontotemporal dementia Rating Scale; FTLD, Frontotemporal Lobar Degeneration; NACC, National Alzheimer’s Disease Coordinating Center.