Table 3

Annualised change in FRS percentage and CDR+NACC FTLD sum of boxes scores in mutation carriers according to baseline CDR+NACC FTLD global rating, and non-carrier controls

CDR+NACC FTLD global rating at baseline	Mutation carriers					Controls
CDR+NACC FTLD global rating at baseline	0	0.5	1	2	3	Controls
N	140	30	22	23	16	145
FRS % Score
Annualised change	−0.5 (8.2)	−2.3 (9.9)	−10.2 (18.6)*, †	−9.6 (16.6)*, †	−2.7 (8.3)	−0.1 (6.0)
CDR+NACC-FTLD-SB
Annualised change	0.2 (0.9)*	0.6 (2.7)	3.0 (4.1)*, †, ‡	4.4 (4.0)*, †, ‡, §	1.7 (3.3)*	−0.1 (0.4)

Values are mean (SD) unless stated.
CDR+NACC FTLD=CDR Dementia Staging Instrument plus Behaviour and Language domains from the NACC FTLD module.
*P<0.05 versus controls
†P<0.05 versus baseline CDR+NACC FTLD global rating=0
‡P<0.05 versus baseline CDR+NACC FTLD global rating=0.5
§P<0.05 versus baseline CDR+NACC FTLD global rating=3.
CDR, Clinical Dementia Rating; FRS, Frontotemporal dementia Rating Scale; FTLD, Frontotemporal Lobar Degeneration; NACC, National Alzheimer’s Disease Coordinating Center.